Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1678-1691 |
| Seitenumfang | 14 |
| Fachzeitschrift | Journal of the American Society for Mass Spectrometry |
| Jahrgang | 33 |
| Ausgabenummer | 9 |
| Frühes Online-Datum | 24 Aug. 2022 |
| Publikationsstatus | Veröffentlicht - 7 Sept. 2022 |
| Extern publiziert | Ja |
Abstract
Glass or metal inlet capillaries are commonly used for flow restriction in atmospheric pressure ionization mass spectrometers. They exhibit a high ion transmission rate and stability at most operating conditions. However, transferring unipolar currents of ions through inlet capillaries can lead to sudden signal dropouts or drifts of the signal intensity, particularly when materials of different conductivity are in contact with the capillary duct. Molecular layers of water and other gases such as liquid chromatography solvents always form on the surfaces of inlet capillaries at atmospheric pressure ionization conditions. These surface layers play a major role in ion transmission and the occurrence of charging effects, as ions adsorb on the capillary walls as well, charging the walls to electric potentials of up to kilovolts and eventually leading to a hindrance of ion transport into or through the capillary duct. In this work, surface charging effects are reported in dependence on the capillary material, i.e., borosilicate glass, (reduced) lead silicate, quartz, and metal. Low electrical conductance materials show a more pronounced long-term signal drift (e.g., quartz), while higher electrical conductance materials lead to stable long-term behavior.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Strukturelle Biologie
- Chemie (insg.)
- Spektroskopie
Zitieren
- Standard
- Harvard
- Apa
- Vancouver
- BibTex
- RIS
in: Journal of the American Society for Mass Spectrometry, Jahrgang 33, Nr. 9, 07.09.2022, S. 1678-1691.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Charging Effects in Inlet Capillaries
AU - Derpmann, Valerie
AU - Müller, David
AU - Haack, Alexander
AU - Wissdorf, Walter
AU - Kersten, Hendrik
AU - Benter, Thorsten
N1 - Funding Information: The authors want to thank Bruker Daltonics, Bremen, Germany, for providing the resistive glass capillary. This work was partially funded by the German Research Foundation (DFG) within projects BE 2124/7-1 and BE 2124/4-1
PY - 2022/9/7
Y1 - 2022/9/7
N2 - Glass or metal inlet capillaries are commonly used for flow restriction in atmospheric pressure ionization mass spectrometers. They exhibit a high ion transmission rate and stability at most operating conditions. However, transferring unipolar currents of ions through inlet capillaries can lead to sudden signal dropouts or drifts of the signal intensity, particularly when materials of different conductivity are in contact with the capillary duct. Molecular layers of water and other gases such as liquid chromatography solvents always form on the surfaces of inlet capillaries at atmospheric pressure ionization conditions. These surface layers play a major role in ion transmission and the occurrence of charging effects, as ions adsorb on the capillary walls as well, charging the walls to electric potentials of up to kilovolts and eventually leading to a hindrance of ion transport into or through the capillary duct. In this work, surface charging effects are reported in dependence on the capillary material, i.e., borosilicate glass, (reduced) lead silicate, quartz, and metal. Low electrical conductance materials show a more pronounced long-term signal drift (e.g., quartz), while higher electrical conductance materials lead to stable long-term behavior.
AB - Glass or metal inlet capillaries are commonly used for flow restriction in atmospheric pressure ionization mass spectrometers. They exhibit a high ion transmission rate and stability at most operating conditions. However, transferring unipolar currents of ions through inlet capillaries can lead to sudden signal dropouts or drifts of the signal intensity, particularly when materials of different conductivity are in contact with the capillary duct. Molecular layers of water and other gases such as liquid chromatography solvents always form on the surfaces of inlet capillaries at atmospheric pressure ionization conditions. These surface layers play a major role in ion transmission and the occurrence of charging effects, as ions adsorb on the capillary walls as well, charging the walls to electric potentials of up to kilovolts and eventually leading to a hindrance of ion transport into or through the capillary duct. In this work, surface charging effects are reported in dependence on the capillary material, i.e., borosilicate glass, (reduced) lead silicate, quartz, and metal. Low electrical conductance materials show a more pronounced long-term signal drift (e.g., quartz), while higher electrical conductance materials lead to stable long-term behavior.
UR - http://www.scopus.com/inward/record.url?scp=85137400327&partnerID=8YFLogxK
U2 - 10.1021/jasms.2c00130
DO - 10.1021/jasms.2c00130
M3 - Article
C2 - 36001770
AN - SCOPUS:85137400327
VL - 33
SP - 1678
EP - 1691
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
SN - 1044-0305
IS - 9
ER -