Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 1526873 |
| Fachzeitschrift | Frontiers in Bioengineering and Biotechnology |
| Jahrgang | 13 |
| Publikationsstatus | Veröffentlicht - 7 Apr. 2025 |
Abstract
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in: Frontiers in Bioengineering and Biotechnology, Jahrgang 13, 1526873, 07.04.2025.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Characterization and modeling of additively manufactured Ti-6Al-4V alloy with modified surfaces for medical applications
AU - Kök, Hüray Ilayda
AU - Andreeva, Tonya
AU - Stammkötter, Sebastian
AU - Reinholdt, Cindy
AU - Akbas, Osman
AU - Jahn, Anne Maren
AU - Gamon, Florian
AU - Fuest, Sandra
AU - Teschke, Mirko
AU - Schäfer, Mirijam
AU - Müller, Michael
AU - Koch, Alexander
AU - Jung, Ole
AU - Barbeck, Mike
AU - Greuling, Andreas
AU - Smeets, Ralf
AU - Hermsdorf, Jörg
AU - Krastev, Rumen
AU - Junker, Philipp
AU - Stiesch, Meike
AU - Walther, Frank
N1 - © 2025 Kök, Andreeva, Stammkötter, Reinholdt, Akbas, Jahn, Gamon, Fuest, Teschke, Schäfer, Michael, Koch, Jung, Barbeck, Greuling, Smeets, Hermsdrof, Krastev, Junker, Stiesch and Walther
PY - 2025/4/7
Y1 - 2025/4/7
N2 - In the field of biomedical implants, additively manufactured titanium alloys, particularly Ti-6Al-4V, hold significant potential due to their biocompatibility and mechanical properties. This study focuses on the characterization and modeling of additively manufactured Ti-6Al-4V alloy for dental and maxillofacial implants, emphasizing fatigue behavior, surface modification, and their combined effects on cyto-and osseocompatibility. Experimental methods, including tensile, compression, and fatigue testing, were applied alongside in-silico simulations to assess the long-term mechanical performance of the material. Surface properties were further modified through sandblasting and coating techniques to enhance cell adhesion and proliferation. By using in-vitro methods, the cytocompatibility of the coatings and materials was examined followed by in-vivo tests to determine osseocompatibility. Results demonstrated that appropriate surface roughness and modifications are essential in optimizing osseointegration, while the layer-by-layer additive manufacturing process influenced the fatigue life and stability. These findings contribute to the development of patient-specific implants, optimizing both mechanical integrity and biological integration for enhanced clinical outcomes. This work summarizes the investigations on additively manufactured Ti-6Al-4V alloy of the research unit 5250 "Mechanism-based characterization and modeling of permanent and bioresorbable implants with tailored functionality based on innovative in vivo, in vitro and in silico methods" funded by the Germany Research Foundation (DFG).
AB - In the field of biomedical implants, additively manufactured titanium alloys, particularly Ti-6Al-4V, hold significant potential due to their biocompatibility and mechanical properties. This study focuses on the characterization and modeling of additively manufactured Ti-6Al-4V alloy for dental and maxillofacial implants, emphasizing fatigue behavior, surface modification, and their combined effects on cyto-and osseocompatibility. Experimental methods, including tensile, compression, and fatigue testing, were applied alongside in-silico simulations to assess the long-term mechanical performance of the material. Surface properties were further modified through sandblasting and coating techniques to enhance cell adhesion and proliferation. By using in-vitro methods, the cytocompatibility of the coatings and materials was examined followed by in-vivo tests to determine osseocompatibility. Results demonstrated that appropriate surface roughness and modifications are essential in optimizing osseointegration, while the layer-by-layer additive manufacturing process influenced the fatigue life and stability. These findings contribute to the development of patient-specific implants, optimizing both mechanical integrity and biological integration for enhanced clinical outcomes. This work summarizes the investigations on additively manufactured Ti-6Al-4V alloy of the research unit 5250 "Mechanism-based characterization and modeling of permanent and bioresorbable implants with tailored functionality based on innovative in vivo, in vitro and in silico methods" funded by the Germany Research Foundation (DFG).
U2 - 10.3389/fbioe.2025.1526873
DO - 10.3389/fbioe.2025.1526873
M3 - Article
VL - 13
JO - Frontiers in Bioengineering and Biotechnology
JF - Frontiers in Bioengineering and Biotechnology
SN - 2296-4185
M1 - 1526873
ER -