Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1284-1289 |
| Seitenumfang | 6 |
| Fachzeitschrift | European Journal of Organic Chemistry |
| Ausgabenummer | 7 |
| Publikationsstatus | Veröffentlicht - 16 Feb. 2010 |
Abstract
The macrolide ketocarbonic acid carolacton (1) was isolated from the myxobacterium Sorangium cellulosum, strain So ce960, because of its antibiotic activity. Subsequently, carolacton (1) was discovered to be a highly potent agent against biofilms containing the caries- and endocarditis-associated bacterium Streptococcus mutans. The 2D structure of 1 was elucidated by HRMS, IR and 2D NMR spectroscopy. Initially, the stereogenic centres were determined by chemical derivatization in combination with computional methods and finally verified by X-ray analysis.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Physikalische und Theoretische Chemie
- Chemie (insg.)
- Organische Chemie
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in: European Journal of Organic Chemistry, Nr. 7, 16.02.2010, S. 1284-1289.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Carolacton - A macrolide ketocarbonic acid that reduces biofilm formation by the caries- and endocarditis-associated bacterium Streptococcus mutans
AU - Jansen, Rolf
AU - Irschik, Herbert
AU - Huch, Volker
AU - Schummer, Dietmar
AU - Steinmetz, Heinrich
AU - Bock, Martin
AU - Schmidt, Thomas
AU - Kirschning, Andreas
AU - Müller, Rolf
PY - 2010/2/16
Y1 - 2010/2/16
N2 - The macrolide ketocarbonic acid carolacton (1) was isolated from the myxobacterium Sorangium cellulosum, strain So ce960, because of its antibiotic activity. Subsequently, carolacton (1) was discovered to be a highly potent agent against biofilms containing the caries- and endocarditis-associated bacterium Streptococcus mutans. The 2D structure of 1 was elucidated by HRMS, IR and 2D NMR spectroscopy. Initially, the stereogenic centres were determined by chemical derivatization in combination with computional methods and finally verified by X-ray analysis.
AB - The macrolide ketocarbonic acid carolacton (1) was isolated from the myxobacterium Sorangium cellulosum, strain So ce960, because of its antibiotic activity. Subsequently, carolacton (1) was discovered to be a highly potent agent against biofilms containing the caries- and endocarditis-associated bacterium Streptococcus mutans. The 2D structure of 1 was elucidated by HRMS, IR and 2D NMR spectroscopy. Initially, the stereogenic centres were determined by chemical derivatization in combination with computional methods and finally verified by X-ray analysis.
KW - Antibiotics
KW - Molecular modeling
KW - Natural products
KW - Structure elucidation
UR - http://www.scopus.com/inward/record.url?scp=77149127719&partnerID=8YFLogxK
U2 - 10.1002/ejoc.200901126
DO - 10.1002/ejoc.200901126
M3 - Article
AN - SCOPUS:77149127719
SP - 1284
EP - 1289
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
SN - 1434-193X
IS - 7
ER -