Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 271-279 |
| Seitenumfang | 9 |
| Fachzeitschrift | Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology |
| Jahrgang | 141 |
| Ausgabenummer | 3 |
| Publikationsstatus | Veröffentlicht - Juli 2005 |
| Extern publiziert | Ja |
Abstract
This study was aimed to test our hypothesis that, in contrast to adult rats, in fetuses and neonates, a large amount of the brain-derived GnRH is delivered to the general circulation. The GnRH concentration and content were estimated in general circulation and in the forebrain in rats on the 18th embryonic day (E18), E21, 3rd postnatal day (P3) and P30-36. Moreover, the GnRH concentration was measured in general circulation on E21 following microsurgical lesion on E18 of the forebrain containing most GnRH neurons. The concentration and content of GnRH in plasma on E18, E21 and P3 enormously exceeded those on P30-36. Reverse was true for the ontogenetic dynamics of the GnRH concentration in the forebrain. The lesion of the forebrain resulted in a drop of the GnRH concentration in plasma. The above data strongly suggest that the forebrain is the principal source of GnRH in general circulation in fetal and neonatal rats. Thus, the brain-derived GnRH is delivered to the general circulation in fetal and neonatal rats in amounts likely sufficient to influence the potential peripheral targets.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Physiologie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Molekularbiologie
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in: Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology, Jahrgang 141, Nr. 3, 07.2005, S. 271-279.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Brain is an important source of GnRH in general circulation in the rat during prenatal and early postnatal ontogenesis
AU - Ugrumov, Michael V.
AU - Sapronova, Anna Ya
AU - Melnikova, Viktoria I.
AU - Proshlyakova, Evgeniya V.
AU - Adamskaya, Elene I.
AU - Lavrentieva, Antonina V.
AU - Nasirova, Diana I.
AU - Babichev, Vasilii N.
N1 - Funding Information: The present study was supported by following grants: RFBR (N 01-04-48761 and N 02-04-49973), Scientific Schools (N NSH-1884.2003.4), Program of the Russian Academy of Sciences: “Integrative Mechanisms in the Regulation of Functions in Organism”. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2005/7
Y1 - 2005/7
N2 - This study was aimed to test our hypothesis that, in contrast to adult rats, in fetuses and neonates, a large amount of the brain-derived GnRH is delivered to the general circulation. The GnRH concentration and content were estimated in general circulation and in the forebrain in rats on the 18th embryonic day (E18), E21, 3rd postnatal day (P3) and P30-36. Moreover, the GnRH concentration was measured in general circulation on E21 following microsurgical lesion on E18 of the forebrain containing most GnRH neurons. The concentration and content of GnRH in plasma on E18, E21 and P3 enormously exceeded those on P30-36. Reverse was true for the ontogenetic dynamics of the GnRH concentration in the forebrain. The lesion of the forebrain resulted in a drop of the GnRH concentration in plasma. The above data strongly suggest that the forebrain is the principal source of GnRH in general circulation in fetal and neonatal rats. Thus, the brain-derived GnRH is delivered to the general circulation in fetal and neonatal rats in amounts likely sufficient to influence the potential peripheral targets.
AB - This study was aimed to test our hypothesis that, in contrast to adult rats, in fetuses and neonates, a large amount of the brain-derived GnRH is delivered to the general circulation. The GnRH concentration and content were estimated in general circulation and in the forebrain in rats on the 18th embryonic day (E18), E21, 3rd postnatal day (P3) and P30-36. Moreover, the GnRH concentration was measured in general circulation on E21 following microsurgical lesion on E18 of the forebrain containing most GnRH neurons. The concentration and content of GnRH in plasma on E18, E21 and P3 enormously exceeded those on P30-36. Reverse was true for the ontogenetic dynamics of the GnRH concentration in the forebrain. The lesion of the forebrain resulted in a drop of the GnRH concentration in plasma. The above data strongly suggest that the forebrain is the principal source of GnRH in general circulation in fetal and neonatal rats. Thus, the brain-derived GnRH is delivered to the general circulation in fetal and neonatal rats in amounts likely sufficient to influence the potential peripheral targets.
KW - Blood-brain barrier
KW - Development
KW - Fetus
KW - Hypothalamus
KW - Plasma
KW - Pregnant rat
KW - Radioimmunoassay
KW - Reproduction
UR - http://www.scopus.com/inward/record.url?scp=23044435345&partnerID=8YFLogxK
U2 - 10.1016/j.cbpb.2005.04.009
DO - 10.1016/j.cbpb.2005.04.009
M3 - Article
C2 - 16009589
AN - SCOPUS:23044435345
VL - 141
SP - 271
EP - 279
JO - Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
JF - Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology
SN - 1095-6433
IS - 3
ER -