Details
Originalsprache | Englisch |
---|---|
Seiten (von - bis) | 65-69 |
Seitenumfang | 5 |
Fachzeitschrift | Lab on a Chip |
Jahrgang | 16 |
Ausgabenummer | 1 |
Frühes Online-Datum | 24 Nov. 2015 |
Publikationsstatus | Veröffentlicht - 2016 |
Extern publiziert | Ja |
Abstract
In droplet-based microfluidics, non-ionic, high-molecular weight surfactants are required to stabilize droplet interfaces. One of the most common structures that imparts stability as well as biocompatibility to water-in-oil droplets is a triblock copolymer surfactant composed of perfluoropolyether (PFPE) and polyethylene glycol (PEG) blocks. However, the fast growing applications of microdroplets in biology would benefit from a larger choice of specialized surfactants. PEG as a hydrophilic moiety, however, is a very limited tool in surfactant modification as one can only vary the molecular weight and chain-end functionalization. In contrast, linear polyglycerol offers further side-chain functionalization to create custom-tailored, biocompatible droplet interfaces. Herein, we describe the synthesis and characterization of polyglycerol-based triblock surfactants with tailored side-chain composition, and exemplify their application in cell encapsulation and in vitro gene expression studies in droplet-based microfluidics.
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Bioengineering
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Chemie (insg.)
- Allgemeine Chemie
- Ingenieurwesen (insg.)
- Biomedizintechnik
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in: Lab on a Chip, Jahrgang 16, Nr. 1, 2016, S. 65-69.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - Biocompatible fluorinated polyglycerols for droplet microfluidics as an alternative to PEG-based copolymer surfactants
AU - Wagner, Olaf
AU - Thiele, Julian
AU - Weinhart, Marie
AU - Mazutis, Linas
AU - Weitz, David A.
AU - Huck, Wilhelm T.S.
AU - Haag, Rainer
N1 - Publisher Copyright: © Royal Society of Chemistry 2016.
PY - 2016
Y1 - 2016
N2 - In droplet-based microfluidics, non-ionic, high-molecular weight surfactants are required to stabilize droplet interfaces. One of the most common structures that imparts stability as well as biocompatibility to water-in-oil droplets is a triblock copolymer surfactant composed of perfluoropolyether (PFPE) and polyethylene glycol (PEG) blocks. However, the fast growing applications of microdroplets in biology would benefit from a larger choice of specialized surfactants. PEG as a hydrophilic moiety, however, is a very limited tool in surfactant modification as one can only vary the molecular weight and chain-end functionalization. In contrast, linear polyglycerol offers further side-chain functionalization to create custom-tailored, biocompatible droplet interfaces. Herein, we describe the synthesis and characterization of polyglycerol-based triblock surfactants with tailored side-chain composition, and exemplify their application in cell encapsulation and in vitro gene expression studies in droplet-based microfluidics.
AB - In droplet-based microfluidics, non-ionic, high-molecular weight surfactants are required to stabilize droplet interfaces. One of the most common structures that imparts stability as well as biocompatibility to water-in-oil droplets is a triblock copolymer surfactant composed of perfluoropolyether (PFPE) and polyethylene glycol (PEG) blocks. However, the fast growing applications of microdroplets in biology would benefit from a larger choice of specialized surfactants. PEG as a hydrophilic moiety, however, is a very limited tool in surfactant modification as one can only vary the molecular weight and chain-end functionalization. In contrast, linear polyglycerol offers further side-chain functionalization to create custom-tailored, biocompatible droplet interfaces. Herein, we describe the synthesis and characterization of polyglycerol-based triblock surfactants with tailored side-chain composition, and exemplify their application in cell encapsulation and in vitro gene expression studies in droplet-based microfluidics.
UR - http://www.scopus.com/inward/record.url?scp=84950104876&partnerID=8YFLogxK
U2 - 10.1039/c5lc00823a
DO - 10.1039/c5lc00823a
M3 - Article
C2 - 26626826
AN - SCOPUS:84950104876
VL - 16
SP - 65
EP - 69
JO - Lab on a Chip
JF - Lab on a Chip
SN - 1473-0197
IS - 1
ER -