Automated Bioreactor System for the Cultivation of Autologous Tissue-Engineered Vascular Grafts

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OriginalspracheEnglisch
Titel des Sammelwerks42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society
UntertitelEnabling Innovative Technologies for Global Healthcare, EMBC 2020
Herausgeber (Verlag)Institute of Electrical and Electronics Engineers Inc.
Seiten2257-2261
Seitenumfang5
ISBN (elektronisch)9781728119908
ISBN (Print)9781728119908
PublikationsstatusVeröffentlicht - 2020
Veranstaltung42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020 - Montreal, Kanada
Dauer: 20 Juli 202024 Juli 2020

Publikationsreihe

NameProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Band2020-July
ISSN (Print)1557-170X

Abstract

In an aging society, diseases associated with irreversible damage of organs are frequent. An increasing percentage of patients requires bioartificial tissue or organ substitutes. Tissue engineering products depend on a well-defined process to ensure successful cultivation while meeting high regulatory demands. The goal of the presented work is the development of a bioreactor system for the cultivation of tissue-engineered vascular grafts (TEVGs) for autologous implantation and transition from a lab scale setup to standardized production. Key characteristics include (i) the automated reliable monitoring and control of a wide-range of parameters regarding implant conditioning, (ii) easy and sterile setup and operation, (iii) reasonable costs of disposables, and (iv) parallelization of automated cultivation processes. The presented prototype bioreactor system provides comprehensive physiologically conditioning, sensing, and imaging functionality to meet all requirements for the successful cultivation of vascular grafts on a productional scale.

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Automated Bioreactor System for the Cultivation of Autologous Tissue-Engineered Vascular Grafts. / Stanislawski, Nils; Cholewa, Fabian; Heymann, Henrik et al.
42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc., 2020. S. 2257-2261 9175340 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Band 2020-July).

Publikation: Beitrag in Buch/Bericht/Sammelwerk/KonferenzbandAufsatz in KonferenzbandForschungPeer-Review

Stanislawski, N, Cholewa, F, Heymann, H, Kraus, X, Heene, S, Witt, M, Thoms, S, Blume, C & Blume, H 2020, Automated Bioreactor System for the Cultivation of Autologous Tissue-Engineered Vascular Grafts. in 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020., 9175340, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Bd. 2020-July, Institute of Electrical and Electronics Engineers Inc., S. 2257-2261, 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society, EMBC 2020, Montreal, Kanada, 20 Juli 2020. https://doi.org/10.1109/embc44109.2020.9175340
Stanislawski, N., Cholewa, F., Heymann, H., Kraus, X., Heene, S., Witt, M., Thoms, S., Blume, C., & Blume, H. (2020). Automated Bioreactor System for the Cultivation of Autologous Tissue-Engineered Vascular Grafts. In 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020 (S. 2257-2261). Artikel 9175340 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Band 2020-July). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/embc44109.2020.9175340
Stanislawski N, Cholewa F, Heymann H, Kraus X, Heene S, Witt M et al. Automated Bioreactor System for the Cultivation of Autologous Tissue-Engineered Vascular Grafts. in 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc. 2020. S. 2257-2261. 9175340. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/embc44109.2020.9175340
Stanislawski, Nils ; Cholewa, Fabian ; Heymann, Henrik et al. / Automated Bioreactor System for the Cultivation of Autologous Tissue-Engineered Vascular Grafts. 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society: Enabling Innovative Technologies for Global Healthcare, EMBC 2020. Institute of Electrical and Electronics Engineers Inc., 2020. S. 2257-2261 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).
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title = "Automated Bioreactor System for the Cultivation of Autologous Tissue-Engineered Vascular Grafts",
abstract = "In an aging society, diseases associated with irreversible damage of organs are frequent. An increasing percentage of patients requires bioartificial tissue or organ substitutes. Tissue engineering products depend on a well-defined process to ensure successful cultivation while meeting high regulatory demands. The goal of the presented work is the development of a bioreactor system for the cultivation of tissue-engineered vascular grafts (TEVGs) for autologous implantation and transition from a lab scale setup to standardized production. Key characteristics include (i) the automated reliable monitoring and control of a wide-range of parameters regarding implant conditioning, (ii) easy and sterile setup and operation, (iii) reasonable costs of disposables, and (iv) parallelization of automated cultivation processes. The presented prototype bioreactor system provides comprehensive physiologically conditioning, sensing, and imaging functionality to meet all requirements for the successful cultivation of vascular grafts on a productional scale.",
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AU - Stanislawski, Nils

AU - Cholewa, Fabian

AU - Heymann, Henrik

AU - Kraus, Xenia

AU - Heene, Sebastian

AU - Witt, Martin

AU - Thoms, Stefanie

AU - Blume, Cornelia

AU - Blume, Holger

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AB - In an aging society, diseases associated with irreversible damage of organs are frequent. An increasing percentage of patients requires bioartificial tissue or organ substitutes. Tissue engineering products depend on a well-defined process to ensure successful cultivation while meeting high regulatory demands. The goal of the presented work is the development of a bioreactor system for the cultivation of tissue-engineered vascular grafts (TEVGs) for autologous implantation and transition from a lab scale setup to standardized production. Key characteristics include (i) the automated reliable monitoring and control of a wide-range of parameters regarding implant conditioning, (ii) easy and sterile setup and operation, (iii) reasonable costs of disposables, and (iv) parallelization of automated cultivation processes. The presented prototype bioreactor system provides comprehensive physiologically conditioning, sensing, and imaging functionality to meet all requirements for the successful cultivation of vascular grafts on a productional scale.

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T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

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BT - 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society

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ER -

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