TY - JOUR

T1 - Association of vitamin E levels with metabolic syndrome, and MRI-derived body fat volumes and liver fat content

AU - Waniek, S.

AU - di Giuseppe, R.

AU - Plachta-Danielzik, S.

AU - Ratjen, I.

AU - Jacobs, G.

AU - Koch, M.

AU - Borggrefe, J.

AU - Both, M.

AU - Müller, H.-P.

AU - Kassubek, J.

AU - Nöthlings, U.

AU - Esatbeyoglu, T.

AU - Schlesinger, S.

AU - Rimbach, G.

AU - Lieb, W.

N1 - Funding information: Acknowledgments: Manja Koch is recipient of a Postdoctoral Research Fellowship from the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG, KO 5187/1-1). Romina di Giuseppe is supported by the Deutsche Forschungsgemeinschaft Excellence Cluster “Inflammation at Interfaces” (grants EXC306 and EXC306/2). The PopGen 2.0 Network is supported by the German Federal Ministry of Education and Research (grant 01GR0468 and 01EY1103). The founding sponsors had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, and in the decision to publish the results.

PY - 2017/10/18

Y1 - 2017/10/18

N2 - We aimed to relate circulating α- and γ-tocopherol levels to a broad spectrum of adiposity-related traits in a cross-sectional Northern German study. Anthropometric measures were obtained, and adipose tissue volumes and liver fat were quantified by magnetic resonance imaging in 641 individuals (mean age 61 years; 40.6% women). Concentrations of α- and γ-tocopherol were measured using high performance liquid chromatography. Multivariable-adjusted linear and logistic regression were used to assess associations of circulating α- and γ-tocopherol/cholesterol ratio levels with visceral (VAT) and subcutaneous adipose tissue (SAT), liver signal intensity (LSI), fatty liver disease (FLD), metabolic syndrome (MetS), and its individual components. The α-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by interquartile range (IQR): 0.036; 95%Confidence Interval (CI): 0.0003; 0.071) and MetS (Odds Ratio (OR): 1.83; 95% CI: 1.21–2.76 for 3rd vs. 1st tertile), and the γ-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by IQR: 0.066; 95% CI: 0.027; 0.104), SAT (β scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23–2.84 for 3rd vs. 1st tertile). α- and γ-tocopherol levels were positively associated with high triglycerides and low high density lipoprotein cholesterol levels (all P trend < 0.05). No association of α- and γ-tocopherol/cholesterol ratio with LSI/FLD was observed. Circulating vitamin E levels displayed strong associations with VAT and MetS. These observations lay the ground for further investigation in longitudinal studies.

AB - We aimed to relate circulating α- and γ-tocopherol levels to a broad spectrum of adiposity-related traits in a cross-sectional Northern German study. Anthropometric measures were obtained, and adipose tissue volumes and liver fat were quantified by magnetic resonance imaging in 641 individuals (mean age 61 years; 40.6% women). Concentrations of α- and γ-tocopherol were measured using high performance liquid chromatography. Multivariable-adjusted linear and logistic regression were used to assess associations of circulating α- and γ-tocopherol/cholesterol ratio levels with visceral (VAT) and subcutaneous adipose tissue (SAT), liver signal intensity (LSI), fatty liver disease (FLD), metabolic syndrome (MetS), and its individual components. The α-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by interquartile range (IQR): 0.036; 95%Confidence Interval (CI): 0.0003; 0.071) and MetS (Odds Ratio (OR): 1.83; 95% CI: 1.21–2.76 for 3rd vs. 1st tertile), and the γ-tocopherol/cholesterol ratio was positively associated with VAT (β scaled by IQR: 0.066; 95% CI: 0.027; 0.104), SAT (β scaled by IQR: 0.048; 95% CI: 0.010; 0.087) and MetS (OR: 1.87; 95% CI: 1.23–2.84 for 3rd vs. 1st tertile). α- and γ-tocopherol levels were positively associated with high triglycerides and low high density lipoprotein cholesterol levels (all P trend < 0.05). No association of α- and γ-tocopherol/cholesterol ratio with LSI/FLD was observed. Circulating vitamin E levels displayed strong associations with VAT and MetS. These observations lay the ground for further investigation in longitudinal studies.

KW - Body fat volumes

KW - Liver fat content

KW - Metabolic syndrome

KW - Vitamin E

KW - α- and γ-tocopherol

UR - http://www.scopus.com/inward/record.url?scp=85032864523&partnerID=8YFLogxK

U2 - 10.3390/nu9101143

DO - 10.3390/nu9101143

M3 - Article

VL - 9

JO - NUTRIENTS

JF - NUTRIENTS

SN - 2072-6643

IS - 10

M1 - 1143

ER -