Details
| Originalsprache | Englisch |
|---|---|
| Aufsatznummer | 1041 |
| Fachzeitschrift | Sensors (Switzerland) |
| Jahrgang | 18 |
| Ausgabenummer | 4 |
| Frühes Online-Datum | 30 Apr. 2018 |
| Publikationsstatus | Veröffentlicht - Apr. 2018 |
Abstract
Magnetic beads (MBs) are versatile tools for the purification, detection, and quantitative analysis of analytes from complex matrices. The superparamagnetic property of magnetic beads qualifies them for various analytical applications. To provide specificity, MBs can be decorated with ligands like aptamers, antibodies and peptides. In this context, aptamers are emerging as particular promising ligands due to a number of advantages. Most importantly, the chemical synthesis of aptamers enables straightforward and controlled chemical modification with linker molecules and dyes. Moreover, aptamers facilitate novel sensing strategies based on their oligonucleotide nature that cannot be realized with conventional peptide-based ligands. Due to these benefits, the combination of aptamers and MBs was already used in various analytical applications which are summarized in this article.
ASJC Scopus Sachgebiete
- Chemie (insg.)
- Analytische Chemie
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biochemie
- Physik und Astronomie (insg.)
- Atom- und Molekularphysik sowie Optik
- Physik und Astronomie (insg.)
- Instrumentierung
- Ingenieurwesen (insg.)
- Elektrotechnik und Elektronik
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in: Sensors (Switzerland), Jahrgang 18, Nr. 4, 1041, 04.2018.
Publikation: Beitrag in Fachzeitschrift › Übersichtsarbeit › Forschung › Peer-Review
}
TY - JOUR
T1 - Aptamer-Modified Magnetic Beads in Biosensing
AU - Modh, Harshvardhan
AU - Scheper, Thomas
AU - Walter, Johanna Gabriela
N1 - Funding information: Acknowledgments: German Academic Exchange Service (DAAD) is acknowledged for the financial support to Harshvardhan Modh. The publication of this article was funded by the Open Access fund of Leibniz Universität Hannover.
PY - 2018/4
Y1 - 2018/4
N2 - Magnetic beads (MBs) are versatile tools for the purification, detection, and quantitative analysis of analytes from complex matrices. The superparamagnetic property of magnetic beads qualifies them for various analytical applications. To provide specificity, MBs can be decorated with ligands like aptamers, antibodies and peptides. In this context, aptamers are emerging as particular promising ligands due to a number of advantages. Most importantly, the chemical synthesis of aptamers enables straightforward and controlled chemical modification with linker molecules and dyes. Moreover, aptamers facilitate novel sensing strategies based on their oligonucleotide nature that cannot be realized with conventional peptide-based ligands. Due to these benefits, the combination of aptamers and MBs was already used in various analytical applications which are summarized in this article.
AB - Magnetic beads (MBs) are versatile tools for the purification, detection, and quantitative analysis of analytes from complex matrices. The superparamagnetic property of magnetic beads qualifies them for various analytical applications. To provide specificity, MBs can be decorated with ligands like aptamers, antibodies and peptides. In this context, aptamers are emerging as particular promising ligands due to a number of advantages. Most importantly, the chemical synthesis of aptamers enables straightforward and controlled chemical modification with linker molecules and dyes. Moreover, aptamers facilitate novel sensing strategies based on their oligonucleotide nature that cannot be realized with conventional peptide-based ligands. Due to these benefits, the combination of aptamers and MBs was already used in various analytical applications which are summarized in this article.
KW - Analytical applications
KW - Aptamer
KW - Electrochemical assays
KW - Magnetic beads
KW - Optical assays
KW - Point-of-care-testing
UR - http://www.scopus.com/inward/record.url?scp=85044941450&partnerID=8YFLogxK
U2 - 10.3390/s18041041
DO - 10.3390/s18041041
M3 - Review article
C2 - 29601533
AN - SCOPUS:85044941450
VL - 18
JO - Sensors (Switzerland)
JF - Sensors (Switzerland)
SN - 1424-8220
IS - 4
M1 - 1041
ER -