Details
| Originalsprache | Englisch |
|---|---|
| Titel des Sammelwerks | Systems and Technologies for Clinical Diagnostics and Drug Discovery II |
| Seiten | 228-239 |
| Seitenumfang | 12 |
| Band | 3603 |
| Publikationsstatus | Veröffentlicht - 21 Apr. 1999 |
| Veranstaltung | BIOS '99 INTERNATIONAL BIOMEDICAL OPTICS SYMPOSIUM - San Jose, CA Dauer: 23 Jan. 1998 → 29 Jan. 1998 |
Publikationsreihe
| Name | Proceedings of SPIE - The International Society for Optical Engineering |
|---|---|
| Herausgeber (Verlag) | SPIE |
| ISSN (Print) | 0277-786X |
Abstract
The new medical developments, e.g. immune therapy, patient orientated chemotherapy or even gene therapy, create a questionable doubt to the further requirement of animal tests. Instead the call for humanitarian reproductive in vitro models becomes increasingly louder. Pharmaceutical usage of in vitro has a long proven history. In cancer research and therapy, the effect of chemostatica in vitro in the so-called oncobiogram is being tested; but the assays do not always correlate with in vivo-like drug resistance and sensitivity. We developed a drug test system in vitro, feasible for therapeutic drug monitoring (TDM) by the combination of tissue cultivation in hollow fiber bioreactors (HFBR) and fiber optic sensors for monitoring the pharmaceutical effect. Using two fiber optic sensors - an optical oxygen sensor (MOPS) and a metabolism detecting Laserfluoroscope (LF), we were able to successfully monitor the biological status of tissue culture and the drug or toxic effects of in vitro pharmaceutical testing. Furthermore, we developed and patented a system for monitoring the effect of minor toxic compounds (VOC) which can induce Sick Building Syndrome (SBS).
ASJC Scopus Sachgebiete
- Werkstoffwissenschaften (insg.)
- Elektronische, optische und magnetische Materialien
- Physik und Astronomie (insg.)
- Physik der kondensierten Materie
- Informatik (insg.)
- Angewandte Informatik
- Mathematik (insg.)
- Angewandte Mathematik
- Ingenieurwesen (insg.)
- Elektrotechnik und Elektronik
Ziele für nachhaltige Entwicklung
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- RIS
Systems and Technologies for Clinical Diagnostics and Drug Discovery II. Band 3603 1999. S. 228-239 (Proceedings of SPIE - The International Society for Optical Engineering).
Publikation: Beitrag in Buch/Bericht/Sammelwerk/Konferenzband › Aufsatz in Konferenzband › Forschung › Peer-Review
}
TY - GEN
T1 - Applying Fiber Optical Methods for Toxicological Testing in Vitro
AU - Maerz, Holger K.
AU - Buchholz, Rainer
AU - Emmrich, Frank
AU - Finks, Frank
AU - Geddes, Clive L.
AU - Pfeifer, Lutz
AU - Raabe, Ferdinand
AU - Scheper, Thomas
AU - Ulrich, Elizabeth
AU - Marx, Uwe
PY - 1999/4/21
Y1 - 1999/4/21
N2 - The new medical developments, e.g. immune therapy, patient orientated chemotherapy or even gene therapy, create a questionable doubt to the further requirement of animal tests. Instead the call for humanitarian reproductive in vitro models becomes increasingly louder. Pharmaceutical usage of in vitro has a long proven history. In cancer research and therapy, the effect of chemostatica in vitro in the so-called oncobiogram is being tested; but the assays do not always correlate with in vivo-like drug resistance and sensitivity. We developed a drug test system in vitro, feasible for therapeutic drug monitoring (TDM) by the combination of tissue cultivation in hollow fiber bioreactors (HFBR) and fiber optic sensors for monitoring the pharmaceutical effect. Using two fiber optic sensors - an optical oxygen sensor (MOPS) and a metabolism detecting Laserfluoroscope (LF), we were able to successfully monitor the biological status of tissue culture and the drug or toxic effects of in vitro pharmaceutical testing. Furthermore, we developed and patented a system for monitoring the effect of minor toxic compounds (VOC) which can induce Sick Building Syndrome (SBS).
AB - The new medical developments, e.g. immune therapy, patient orientated chemotherapy or even gene therapy, create a questionable doubt to the further requirement of animal tests. Instead the call for humanitarian reproductive in vitro models becomes increasingly louder. Pharmaceutical usage of in vitro has a long proven history. In cancer research and therapy, the effect of chemostatica in vitro in the so-called oncobiogram is being tested; but the assays do not always correlate with in vivo-like drug resistance and sensitivity. We developed a drug test system in vitro, feasible for therapeutic drug monitoring (TDM) by the combination of tissue cultivation in hollow fiber bioreactors (HFBR) and fiber optic sensors for monitoring the pharmaceutical effect. Using two fiber optic sensors - an optical oxygen sensor (MOPS) and a metabolism detecting Laserfluoroscope (LF), we were able to successfully monitor the biological status of tissue culture and the drug or toxic effects of in vitro pharmaceutical testing. Furthermore, we developed and patented a system for monitoring the effect of minor toxic compounds (VOC) which can induce Sick Building Syndrome (SBS).
UR - http://www.scopus.com/inward/record.url?scp=0032640437&partnerID=8YFLogxK
U2 - 10.1117/12.346746
DO - 10.1117/12.346746
M3 - Conference contribution
AN - SCOPUS:0032640437
VL - 3603
T3 - Proceedings of SPIE - The International Society for Optical Engineering
SP - 228
EP - 239
BT - Systems and Technologies for Clinical Diagnostics and Drug Discovery II
T2 - BIOS '99 INTERNATIONAL BIOMEDICAL OPTICS SYMPOSIUM
Y2 - 23 January 1998 through 29 January 1998
ER -