TY - JOUR

T1 - Application of In Situ Product Crystallization and Related Techniques in Biocatalytic Processes

AU - Hülsewede, Dennis

AU - Meyer, Lars-Erik

AU - von Langermann, Jan

N1 - Funding information: We thank Prof. Udo Kragl (University of Rostock, Germany), Prof. Uwe Bornscheuer (University of Greifswald, Germany), and Prof. Andreas Seidel-Morgenstern (Otto von Guericke University Magdeburg, Germany) for their ongoing support and useful discussions. Funding for D.H. by the DFG (Deutsche Forschungsgemeinschaft, grant number LA 4183/1-1), for L.E.M. by the DFG (grant number KR 2491/11-1), and for J.v.L. by the BMBF (Bundesministerium für Bildung und Forschung; grant number: 031A123) is gratefully acknowledged. This research project is cofunded by the Leibniz Science Campus Phosphorus Research Rostock. We also thank Johanna Claus for her creative assistance with the TOC figure. We thank Prof. Udo Kragl (University of Rostock, Germany), Prof. Uwe Bornscheuer (University of Greifswald, Germany), and Prof. Andreas Seidel-Morgenstern (Otto von Guericke University Magdeburg, Germany) for their ongoing support and useful discussions. Funding for D.H. by the DFG (Deutsche For-schungsgemeinschaft, grant number LA 4183/1-1), for L.E.M. by the DFG (grant number KR 2491/11-1), and for J.v.L. by the BMBF (Bundesministerium für Bildung und Forschung; grant number: 031A123) is gratefully acknowledged. This research project is cofunded by the Leibniz Science Campus Phosphorus Research Rostock. We also thank Johanna Claus for her creative assistance with the TOC figure.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - This Minireview highlights the application of crystallization as a very powerful in situ product removal (ISPR) technique in biocatalytic process design. Special emphasis is placed on its use for in situ product crystallization (ISPC) to overcome unfavorable thermodynamic reaction equilibria, inhibition, and undesired reactions. The combination of these unit operations requires an interdisciplinary perspective to find a holistic solution for the underlying bioprocess intensification approach. Representative examples of successful integrated process options are selected, presented, and assessed regarding their overall productivity and applicability. In addition, parallels to the use of adsorption as a very similar technique are drawn and similarities discussed.

AB - This Minireview highlights the application of crystallization as a very powerful in situ product removal (ISPR) technique in biocatalytic process design. Special emphasis is placed on its use for in situ product crystallization (ISPC) to overcome unfavorable thermodynamic reaction equilibria, inhibition, and undesired reactions. The combination of these unit operations requires an interdisciplinary perspective to find a holistic solution for the underlying bioprocess intensification approach. Representative examples of successful integrated process options are selected, presented, and assessed regarding their overall productivity and applicability. In addition, parallels to the use of adsorption as a very similar technique are drawn and similarities discussed.

KW - biosynthesis

KW - crystal growth

KW - enzymes

KW - in situ product removal

KW - process intensification

UR - http://www.scopus.com/inward/record.url?scp=85060568205&partnerID=8YFLogxK

U2 - 10.1002/chem.201804970

DO - 10.1002/chem.201804970

M3 - Review article

C2 - 30395380

AN - SCOPUS:85060568205

VL - 25

SP - 4871

EP - 4884

JO - Chemistry - a European journal

JF - Chemistry - a European journal

SN - 0947-6539

IS - 19

ER -