ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Autoren

  • Christian Von Loeffelholz
  • Andreas F.H. Pfeiffer
  • Johan F. Lock
  • Steffi Lieske
  • Stephanie Döcke
  • Veronica Murahovschi
  • Jennifer Kriebel
  • Tonia De Las Heras Gala
  • Harald Grallert
  • Natalia Rudovich
  • Martin Stockmann
  • Joachim Spranger
  • Gerhard Jahreis
  • Stefan R. Bornstein
  • George Lau
  • Aimin Xu
  • Jeanette Schulz-Menger
  • Louisa Exner
  • Sven Haufe
  • Jens Jordan
  • Stefan Engeli
  • Andreas L. Birkenfeld

Externe Organisationen

  • Deutsches Institut für Ernährungsforschung
  • Friedrich-Schiller-Universität Jena
  • Charité - Universitätsmedizin Berlin
  • Deutsches Zentrum für Diabetesforschung e.V. (DZD)
  • Julius-Maximilians-Universität Würzburg
  • Universitätsklinikum Carl Gustav Carus Dresden
  • Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
  • The University of Hong Kong
  • Medizinische Hochschule Hannover (MHH)
  • Deutsches Zentrum für Luft- und Raumfahrt e.V. (DLR)
  • Technische Universität Dresden
  • King's College London
  • Max-Delbrück-Centrum für Molekulare Medizin (MDC) in der Helmholtz-Gemeinschaft
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Seiten (von - bis)343-349
Seitenumfang7
FachzeitschriftHormone and metabolic research
Jahrgang49
Ausgabenummer5
Frühes Online-Datum28 März 2017
PublikationsstatusVeröffentlicht - 1 Mai 2017
Extern publiziertJa

Abstract

Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated. Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=−0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.

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ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. / Von Loeffelholz, Christian; Pfeiffer, Andreas F.H.; Lock, Johan F. et al.
in: Hormone and metabolic research, Jahrgang 49, Nr. 5, 01.05.2017, S. 343-349.

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Von Loeffelholz, C, Pfeiffer, AFH, Lock, JF, Lieske, S, Döcke, S, Murahovschi, V, Kriebel, J, De Las Heras Gala, T, Grallert, H, Rudovich, N, Stockmann, M, Spranger, J, Jahreis, G, Bornstein, SR, Lau, G, Xu, A, Schulz-Menger, J, Exner, L, Haufe, S, Jordan, J, Engeli, S & Birkenfeld, AL 2017, 'ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives', Hormone and metabolic research, Jg. 49, Nr. 5, S. 343-349. https://doi.org/10.1055/s-0043-102950
Von Loeffelholz, C., Pfeiffer, A. F. H., Lock, J. F., Lieske, S., Döcke, S., Murahovschi, V., Kriebel, J., De Las Heras Gala, T., Grallert, H., Rudovich, N., Stockmann, M., Spranger, J., Jahreis, G., Bornstein, S. R., Lau, G., Xu, A., Schulz-Menger, J., Exner, L., Haufe, S., ... Birkenfeld, A. L. (2017). ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. Hormone and metabolic research, 49(5), 343-349. https://doi.org/10.1055/s-0043-102950
Von Loeffelholz C, Pfeiffer AFH, Lock JF, Lieske S, Döcke S, Murahovschi V et al. ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. Hormone and metabolic research. 2017 Mai 1;49(5):343-349. Epub 2017 Mär 28. doi: 10.1055/s-0043-102950
Von Loeffelholz, Christian ; Pfeiffer, Andreas F.H. ; Lock, Johan F. et al. / ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. in: Hormone and metabolic research. 2017 ; Jahrgang 49, Nr. 5. S. 343-349.
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title = "ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives",
abstract = "Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated. Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=−0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.",
keywords = "diabetes, fatty acids, fatty liver, HDL, hepatokine, insulin resistance, LDL, triacylglycerides",
author = "{Von Loeffelholz}, Christian and Pfeiffer, {Andreas F.H.} and Lock, {Johan F.} and Steffi Lieske and Stephanie D{\"o}cke and Veronica Murahovschi and Jennifer Kriebel and {De Las Heras Gala}, Tonia and Harald Grallert and Natalia Rudovich and Martin Stockmann and Joachim Spranger and Gerhard Jahreis and Bornstein, {Stefan R.} and George Lau and Aimin Xu and Jeanette Schulz-Menger and Louisa Exner and Sven Haufe and Jens Jordan and Stefan Engeli and Birkenfeld, {Andreas L.}",
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Download

TY - JOUR

T1 - ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives

AU - Von Loeffelholz, Christian

AU - Pfeiffer, Andreas F.H.

AU - Lock, Johan F.

AU - Lieske, Steffi

AU - Döcke, Stephanie

AU - Murahovschi, Veronica

AU - Kriebel, Jennifer

AU - De Las Heras Gala, Tonia

AU - Grallert, Harald

AU - Rudovich, Natalia

AU - Stockmann, Martin

AU - Spranger, Joachim

AU - Jahreis, Gerhard

AU - Bornstein, Stefan R.

AU - Lau, George

AU - Xu, Aimin

AU - Schulz-Menger, Jeanette

AU - Exner, Louisa

AU - Haufe, Sven

AU - Jordan, Jens

AU - Engeli, Stefan

AU - Birkenfeld, Andreas L.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated. Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=−0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.

AB - Angiopoietin-like protein 8 (ANGPTL8)/betatrophin expression in visceral adipose tissue and associations with circulating fatty acid profile have not yet been investigated. Forty subjects were included in a cross-sectional study, 57 in a dietary weight reduction intervention. Circulating Angiopoietin-like protein 8/betatrophin was measured in all subjects. Liver and adipose tissue were sampled and plasma fatty acids and tissue Angiopoietin-like protein 8/betatrophin expression were evaluated in the cross-sectional study. In the intervention study oral glucose testing and liver magnetic resonance scanning at baseline and after 6 months were performed. Angiopoietin-like protein 8/betatrophin mRNA was increased in visceral compared to subcutaneous adipose tissue (p<0.001). Circulating ANGPTL8/betatrophin correlated with liver steatosis (r=0.42, p=0.047), triacylglycerols (r=0.34, p=0.046), saturated (r=0.43, p=0.022), monounsaturated (r=0.51, p=0.007), and polyunsaturated fatty acids (r=−0.53, p=0.004). In the intervention study, baseline Angiopoietin-like protein 8/betatrophin correlated with age (r=0.32, p=0.010) and triacylglycerols (r=0.30, p=0.02) and was increased with hepatic steatosis (p=0.033). Weight loss reduced liver fat by 45% and circulating Angiopoietin-like protein 8/betatrophin by 11% (288±17 vs. 258±17 pg/ml; p=0.015). Angiopoietin-like protein 8/betatrophin is related to liver steatosis, while visceral adipose tissue represents an additional site of expression in humans.

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KW - fatty acids

KW - fatty liver

KW - HDL

KW - hepatokine

KW - insulin resistance

KW - LDL

KW - triacylglycerides

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