An integrated process for the production and biotransformation of penicillin

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OriginalspracheEnglisch
Seiten (von - bis)143-154
Seitenumfang12
FachzeitschriftJournal of biotechnology
Jahrgang26
Ausgabenummer2-3
PublikationsstatusVeröffentlicht - Nov. 1992

Abstract

The extraction of Penicillin G (PG) from the filtered cultivation medium of Penicillium chrysogenum and its conversion into 6-amino penicillanic acid (6-APA) and phenyl acetic acid (PhA) at pH 8 was performed in a 10 l Kühni extractor during the production by means of penicillin-G-amidase immobilized in a liquid membrane carrier system (LM). 6-APA was enriched in LM, and the PhA returned to the cultivation medium. After electrocoalescence of LM, the 6-APA was converted into ampicillin with the same enzyme at pH 6, while the liquid membrane phase and enzyme were recycled and reused.

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An integrated process for the production and biotransformation of penicillin. / Barenschee, T.; Scheper, T.; Schügerl, K.
in: Journal of biotechnology, Jahrgang 26, Nr. 2-3, 11.1992, S. 143-154.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Barenschee T, Scheper T, Schügerl K. An integrated process for the production and biotransformation of penicillin. Journal of biotechnology. 1992 Nov;26(2-3):143-154. doi: 10.1016/0168-1656(92)90002-Q
Barenschee, T. ; Scheper, T. ; Schügerl, K. / An integrated process for the production and biotransformation of penicillin. in: Journal of biotechnology. 1992 ; Jahrgang 26, Nr. 2-3. S. 143-154.
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note = "Funding information: The authors acknowledge Hoechst Co., H6chst, and the Swedish Scientific Foundation for the financial support, and thank Prof. Setterwall as well as Dr. A. Hasler, Dr. S. Hotop, Dr. A. Neumann, Dr. C. Nowottny, and Dr. D. Tsikas for their cooperation.",
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AU - Barenschee, T.

AU - Scheper, T.

AU - Schügerl, K.

N1 - Funding information: The authors acknowledge Hoechst Co., H6chst, and the Swedish Scientific Foundation for the financial support, and thank Prof. Setterwall as well as Dr. A. Hasler, Dr. S. Hotop, Dr. A. Neumann, Dr. C. Nowottny, and Dr. D. Tsikas for their cooperation.

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KW - Penicillin G-amidase

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