TY - JOUR

T1 - Adaptive optics assisted and optical coherence tomography guided fs-laser system for ophthalmic surgery in the posterior eye

AU - Matthias, Ben

AU - Zabic, Miroslav

AU - Brockmann, Dorothee

AU - Krueger, Alexander

AU - Ripken, Tammo

N1 - Publisher Copyright: © 2016 Society of Photo-Optical Instrumentation Engineers (SPIE).

PY - 2016/12/14

Y1 - 2016/12/14

N2 - While fs-lasers are clinically established for surgery in the anterior eye, their use in the posterior eye is impeded by aberrations and focus position errors. We implemented a laboratory system to investigate whether fs-laser surgery in the posterior eye is made more feasible by aberration correction and tomographic image guidance. Aberration correction is obtained by adaptive optics (AO) and the image guidance is accomplished by optical coherence tomography (OCT). System characteristic measurements and cutting experiments were performed inside an eye model. By aberration correction, wavefront errors were reduced from 270 nm root-mean-square (rms) to 64 nm rms, ignoring Zernike terms for tilts and focus. The Strehl ratio of the assigned point spread function is improved from 0.11 to 0.78. The threshold pulse energy of laser-induced optical breakdown in water is lowered from about 3.0 to about 1.3 μJ measured at the eye model entrance. After laser cutting of a synthetic foil placed 300 μm in front of porcine retinal tissue with the corrected system, postoperative three-dimensional OCT imaging showed no lesions in the tissue. Our results corroborate that AO and OCT will be two essential assistive components for possible clinical systems for fs-laser-based surgery in the posterior eye.

AB - While fs-lasers are clinically established for surgery in the anterior eye, their use in the posterior eye is impeded by aberrations and focus position errors. We implemented a laboratory system to investigate whether fs-laser surgery in the posterior eye is made more feasible by aberration correction and tomographic image guidance. Aberration correction is obtained by adaptive optics (AO) and the image guidance is accomplished by optical coherence tomography (OCT). System characteristic measurements and cutting experiments were performed inside an eye model. By aberration correction, wavefront errors were reduced from 270 nm root-mean-square (rms) to 64 nm rms, ignoring Zernike terms for tilts and focus. The Strehl ratio of the assigned point spread function is improved from 0.11 to 0.78. The threshold pulse energy of laser-induced optical breakdown in water is lowered from about 3.0 to about 1.3 μJ measured at the eye model entrance. After laser cutting of a synthetic foil placed 300 μm in front of porcine retinal tissue with the corrected system, postoperative three-dimensional OCT imaging showed no lesions in the tissue. Our results corroborate that AO and OCT will be two essential assistive components for possible clinical systems for fs-laser-based surgery in the posterior eye.

KW - ophthalmic laser surgery

KW - posterior eye segment

KW - fs-laser

KW - adaptive optics

KW - aberrations

KW - optical coherence tomography

UR - http://www.scopus.com/inward/record.url?scp=85007197226&partnerID=8YFLogxK

U2 - 10.1117/1.JBO.21.12.121512

DO - 10.1117/1.JBO.21.12.121512

M3 - Article

VL - 21

JO - Journal of biomedical optics

JF - Journal of biomedical optics

SN - 1083-3668

IS - 12

M1 - 121512

ER -