Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1425-1430 |
| Seitenumfang | 6 |
| Fachzeitschrift | Journal of the American Society for Mass Spectrometry |
| Jahrgang | 29 |
| Ausgabenummer | 7 |
| Frühes Online-Datum | 8 Mai 2018 |
| Publikationsstatus | Veröffentlicht - 1 Juli 2018 |
Abstract
Corona discharge ionization sources are often used in ion mobility spectrometers (IMS) when a non-radioactive ion source with high ion currents is required. Typically, the corona discharge is followed by a reaction region where analyte ions are formed from the reactant ions. In this work, we present a simple yet sufficiently accurate model for predicting the ion current available at the end of this reaction region when operating at reduced pressure as in High Kinetic Energy Ion Mobility Spectrometers (HiKE-IMS) or most IMS-MS instruments. It yields excellent qualitative agreement with measurement results and is even able to calculate the ion current within an error of 15%. Additional interesting findings of this model are the ion current at the end of the reaction region being independent from the ion current generated by the corona discharge and the ion current in High Kinetic Energy Ion Mobility Spectrometers (HiKE-IMS) growing quadratically when scaling down the length of the reaction region.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Strukturelle Biologie
- Chemie (insg.)
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in: Journal of the American Society for Mass Spectrometry, Jahrgang 29, Nr. 7, 01.07.2018, S. 1425-1430.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - A Simple Analytical Model for Predicting the Detectable Ion Current in Ion Mobility Spectrometry Using Corona Discharge Ionization Sources
AU - Kirk, Ansgar Thomas
AU - Kobelt, Tim
AU - Spehlbrink, Hauke
AU - Zimmermann, Stefan
N1 - Funding information: This study was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – ZI 1288/7-1.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Corona discharge ionization sources are often used in ion mobility spectrometers (IMS) when a non-radioactive ion source with high ion currents is required. Typically, the corona discharge is followed by a reaction region where analyte ions are formed from the reactant ions. In this work, we present a simple yet sufficiently accurate model for predicting the ion current available at the end of this reaction region when operating at reduced pressure as in High Kinetic Energy Ion Mobility Spectrometers (HiKE-IMS) or most IMS-MS instruments. It yields excellent qualitative agreement with measurement results and is even able to calculate the ion current within an error of 15%. Additional interesting findings of this model are the ion current at the end of the reaction region being independent from the ion current generated by the corona discharge and the ion current in High Kinetic Energy Ion Mobility Spectrometers (HiKE-IMS) growing quadratically when scaling down the length of the reaction region.
AB - Corona discharge ionization sources are often used in ion mobility spectrometers (IMS) when a non-radioactive ion source with high ion currents is required. Typically, the corona discharge is followed by a reaction region where analyte ions are formed from the reactant ions. In this work, we present a simple yet sufficiently accurate model for predicting the ion current available at the end of this reaction region when operating at reduced pressure as in High Kinetic Energy Ion Mobility Spectrometers (HiKE-IMS) or most IMS-MS instruments. It yields excellent qualitative agreement with measurement results and is even able to calculate the ion current within an error of 15%. Additional interesting findings of this model are the ion current at the end of the reaction region being independent from the ion current generated by the corona discharge and the ion current in High Kinetic Energy Ion Mobility Spectrometers (HiKE-IMS) growing quadratically when scaling down the length of the reaction region.
KW - Analytical model
KW - Corona
KW - High kinetic energy ion mobility spectrometry
KW - Ion current
KW - Ion mobility spectrometry
UR - http://www.scopus.com/inward/record.url?scp=85048607584&partnerID=8YFLogxK
U2 - 10.15488/4401
DO - 10.15488/4401
M3 - Article
C2 - 29740761
AN - SCOPUS:85048607584
VL - 29
SP - 1425
EP - 1430
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
SN - 1044-0305
IS - 7
ER -