Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 1455-1467 |
| Seitenumfang | 13 |
| Fachzeitschrift | European Archives of Oto-Rhino-Laryngology |
| Jahrgang | 273 |
| Ausgabenummer | 6 |
| Publikationsstatus | Veröffentlicht - 4 Sept. 2015 |
Abstract
The frontal sinus recess consists of anatomically narrow passages that are prone to stenosis in endonasal frontal sinus surgery for chronic sinus disease. Over the past 100 years, diverse frontal sinus stents have been developed and evaluated in clinical and animal studies. However, superinfection, formation of granulations tissue, stent dislocation and late stenosis of the duct have remained challenges and subject of debate in the literature. Currently developed biodegradable materials, including rare earth-containing magnesium alloys are promising candidates for application as temporary implant materials. The Mg 2 % wt Nd alloy (MgNd2) was used to design a nasal stent that fit the porcine anatomy. In the current study, we evaluate biocompatibility, biodegradation and functionality of a frontal sinus stent in 16 minipigs over 6 months. Intraoperative endoscopy revealed free stent lumen in all cases. Blood examination and clinical examinations indicated no systematic or local inflammation signs. The histopathology and elements analysis showed a very good biocompatibility. The μ-computed tomography-based volumetric analysis showed substantial stent degradation within 6 months. Our MgNd2 based stent appears to be a promising, solid basis for the development of a frontal sinus stent for clinical use.
ASJC Scopus Sachgebiete
- Medizin (insg.)
- Hals-Nasen-Ohrenheilkunde
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in: European Archives of Oto-Rhino-Laryngology, Jahrgang 273, Nr. 6, 04.09.2015, S. 1455-1467.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - A novel biodegradable frontal sinus stent (MgNd2)
T2 - a long-term animal study
AU - Durisin, M.
AU - Seitz, J. M.
AU - Reifenrath, J.
AU - Weber, C. M.
AU - Eifler, R.
AU - Maier, H. J.
AU - Lenarz, T.
AU - Klose, C.
N1 - Funding information: This study was conducted within the Collaborative Research Centre SFB 599, which is funded by the German Research Foundation (DFG). Special thanks go to Melanie Steffens for her extremely valuable technical support.
PY - 2015/9/4
Y1 - 2015/9/4
N2 - The frontal sinus recess consists of anatomically narrow passages that are prone to stenosis in endonasal frontal sinus surgery for chronic sinus disease. Over the past 100 years, diverse frontal sinus stents have been developed and evaluated in clinical and animal studies. However, superinfection, formation of granulations tissue, stent dislocation and late stenosis of the duct have remained challenges and subject of debate in the literature. Currently developed biodegradable materials, including rare earth-containing magnesium alloys are promising candidates for application as temporary implant materials. The Mg 2 % wt Nd alloy (MgNd2) was used to design a nasal stent that fit the porcine anatomy. In the current study, we evaluate biocompatibility, biodegradation and functionality of a frontal sinus stent in 16 minipigs over 6 months. Intraoperative endoscopy revealed free stent lumen in all cases. Blood examination and clinical examinations indicated no systematic or local inflammation signs. The histopathology and elements analysis showed a very good biocompatibility. The μ-computed tomography-based volumetric analysis showed substantial stent degradation within 6 months. Our MgNd2 based stent appears to be a promising, solid basis for the development of a frontal sinus stent for clinical use.
AB - The frontal sinus recess consists of anatomically narrow passages that are prone to stenosis in endonasal frontal sinus surgery for chronic sinus disease. Over the past 100 years, diverse frontal sinus stents have been developed and evaluated in clinical and animal studies. However, superinfection, formation of granulations tissue, stent dislocation and late stenosis of the duct have remained challenges and subject of debate in the literature. Currently developed biodegradable materials, including rare earth-containing magnesium alloys are promising candidates for application as temporary implant materials. The Mg 2 % wt Nd alloy (MgNd2) was used to design a nasal stent that fit the porcine anatomy. In the current study, we evaluate biocompatibility, biodegradation and functionality of a frontal sinus stent in 16 minipigs over 6 months. Intraoperative endoscopy revealed free stent lumen in all cases. Blood examination and clinical examinations indicated no systematic or local inflammation signs. The histopathology and elements analysis showed a very good biocompatibility. The μ-computed tomography-based volumetric analysis showed substantial stent degradation within 6 months. Our MgNd2 based stent appears to be a promising, solid basis for the development of a frontal sinus stent for clinical use.
KW - Animal study
KW - Chronic sinusitis
KW - Frontal stent
KW - Magnesium alloys
KW - Sinus surgery
KW - μ-computed tomography
UR - http://www.scopus.com/inward/record.url?scp=84940844227&partnerID=8YFLogxK
U2 - 10.1007/s00405-015-3774-7
DO - 10.1007/s00405-015-3774-7
M3 - Article
C2 - 26341887
AN - SCOPUS:84940844227
VL - 273
SP - 1455
EP - 1467
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
SN - 0937-4477
IS - 6
ER -