A Novel Artificial Coronary Plaque to Model Coronary Heart Disease

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Philipp Lindenhahn
  • Jannik Richter
  • Iliyana Pepelanova
  • Bettina Seeger
  • Holger A. Volk
  • Rabea Hinkel
  • Bernhard Hiebl
  • Thomas Scheper
  • Jan B. Hinrichs
  • Lena S. Becker
  • Axel Haverich
  • Tim Kaufeld

Organisationseinheiten

Externe Organisationen

  • Medizinische Hochschule Hannover (MHH)
  • Stiftung Tierärztliche Hochschule Hannover
  • Deutsches Primatenzentrum GmbH - Leibniz-Institut für Primatenforschung (DPZ)
  • Deutsches Zentrum für Herz-Kreislauf-Forschung eV
Forschungs-netzwerk anzeigen

Details

OriginalspracheEnglisch
Aufsatznummer197
Seitenumfang15
FachzeitschriftBiomimetics
Jahrgang9
Ausgabenummer4
PublikationsstatusVeröffentlicht - 26 März 2024

Abstract

Background: Experimental coronary artery interventions are currently being performed on non-diseased blood vessels in healthy animals. To provide a more realistic pathoanatomical scenario for investigations on novel interventional and surgical therapies, we aimed to fabricate a stenotic lesion, mimicking the morphology and structure of a human atherosclerotic plaque. Methods: In an interdisciplinary setting, we engineered a casting mold to create an atherosclerotic plaque with the dimensions to fit in a porcine coronary artery. Oscillatory rheology experiments took place along with long-term stability tests assessed by microscopic examination and weight monitoring. For the implantability in future in vivo setups, we performed a cytotoxicity assessment, inserted the plaque in resected pig hearts, and performed diagnostic imaging to visualize the plaque in its final position. Results: The most promising composition consists of gelatin, cholesterol, phospholipids, hydroxyapatite, and fine-grained calcium carbonate. It can be inserted in the coronary artery of human-sized pig hearts, producing a local partial stenosis and interacting like the atherosclerotic plaque by stretching and shrinking with the vessel wall and surrounding tissue. Conclusion: This artificial atherosclerotic plaque model works as a simulating tool for future medical testing and could be crucial for further specified research on coronary artery disease and is going to help to provide information about the optimal interventional and surgical care of the disease.

ASJC Scopus Sachgebiete

Ziele für nachhaltige Entwicklung

Zitieren

A Novel Artificial Coronary Plaque to Model Coronary Heart Disease. / Lindenhahn, Philipp; Richter, Jannik; Pepelanova, Iliyana et al.
in: Biomimetics, Jahrgang 9, Nr. 4, 197, 26.03.2024.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Lindenhahn, P, Richter, J, Pepelanova, I, Seeger, B, Volk, HA, Hinkel, R, Hiebl, B, Scheper, T, Hinrichs, JB, Becker, LS, Haverich, A & Kaufeld, T 2024, 'A Novel Artificial Coronary Plaque to Model Coronary Heart Disease', Biomimetics, Jg. 9, Nr. 4, 197. https://doi.org/10.3390/biomimetics9040197
Lindenhahn, P., Richter, J., Pepelanova, I., Seeger, B., Volk, H. A., Hinkel, R., Hiebl, B., Scheper, T., Hinrichs, J. B., Becker, L. S., Haverich, A., & Kaufeld, T. (2024). A Novel Artificial Coronary Plaque to Model Coronary Heart Disease. Biomimetics, 9(4), Artikel 197. https://doi.org/10.3390/biomimetics9040197
Lindenhahn P, Richter J, Pepelanova I, Seeger B, Volk HA, Hinkel R et al. A Novel Artificial Coronary Plaque to Model Coronary Heart Disease. Biomimetics. 2024 Mär 26;9(4):197. doi: 10.3390/biomimetics9040197
Lindenhahn, Philipp ; Richter, Jannik ; Pepelanova, Iliyana et al. / A Novel Artificial Coronary Plaque to Model Coronary Heart Disease. in: Biomimetics. 2024 ; Jahrgang 9, Nr. 4.
Download
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abstract = "Background: Experimental coronary artery interventions are currently being performed on non-diseased blood vessels in healthy animals. To provide a more realistic pathoanatomical scenario for investigations on novel interventional and surgical therapies, we aimed to fabricate a stenotic lesion, mimicking the morphology and structure of a human atherosclerotic plaque. Methods: In an interdisciplinary setting, we engineered a casting mold to create an atherosclerotic plaque with the dimensions to fit in a porcine coronary artery. Oscillatory rheology experiments took place along with long-term stability tests assessed by microscopic examination and weight monitoring. For the implantability in future in vivo setups, we performed a cytotoxicity assessment, inserted the plaque in resected pig hearts, and performed diagnostic imaging to visualize the plaque in its final position. Results: The most promising composition consists of gelatin, cholesterol, phospholipids, hydroxyapatite, and fine-grained calcium carbonate. It can be inserted in the coronary artery of human-sized pig hearts, producing a local partial stenosis and interacting like the atherosclerotic plaque by stretching and shrinking with the vessel wall and surrounding tissue. Conclusion: This artificial atherosclerotic plaque model works as a simulating tool for future medical testing and could be crucial for further specified research on coronary artery disease and is going to help to provide information about the optimal interventional and surgical care of the disease.",
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AU - Richter, Jannik

AU - Pepelanova, Iliyana

AU - Seeger, Bettina

AU - Volk, Holger A.

AU - Hinkel, Rabea

AU - Hiebl, Bernhard

AU - Scheper, Thomas

AU - Hinrichs, Jan B.

AU - Becker, Lena S.

AU - Haverich, Axel

AU - Kaufeld, Tim

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N2 - Background: Experimental coronary artery interventions are currently being performed on non-diseased blood vessels in healthy animals. To provide a more realistic pathoanatomical scenario for investigations on novel interventional and surgical therapies, we aimed to fabricate a stenotic lesion, mimicking the morphology and structure of a human atherosclerotic plaque. Methods: In an interdisciplinary setting, we engineered a casting mold to create an atherosclerotic plaque with the dimensions to fit in a porcine coronary artery. Oscillatory rheology experiments took place along with long-term stability tests assessed by microscopic examination and weight monitoring. For the implantability in future in vivo setups, we performed a cytotoxicity assessment, inserted the plaque in resected pig hearts, and performed diagnostic imaging to visualize the plaque in its final position. Results: The most promising composition consists of gelatin, cholesterol, phospholipids, hydroxyapatite, and fine-grained calcium carbonate. It can be inserted in the coronary artery of human-sized pig hearts, producing a local partial stenosis and interacting like the atherosclerotic plaque by stretching and shrinking with the vessel wall and surrounding tissue. Conclusion: This artificial atherosclerotic plaque model works as a simulating tool for future medical testing and could be crucial for further specified research on coronary artery disease and is going to help to provide information about the optimal interventional and surgical care of the disease.

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