Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 2004-2005 |
| Seitenumfang | 2 |
| Fachzeitschrift | Chemical communications |
| Jahrgang | 2 |
| Ausgabenummer | 18 |
| Publikationsstatus | Veröffentlicht - 1 Jan. 2002 |
| Extern publiziert | Ja |
Abstract
A new, mild and high yielding synthesis of phosphoramidates is described: potassium salts of carboxylic acids are treated with ethylchloroformate and the resulting activated anhydride-carbonates are then treated with LiNHP(O)(OEt)2 in situ—the methodology is especially suited to acid sensitive systems featuring BOC,tBu or acetal protecting groups.
ASJC Scopus Sachgebiete
- Chemische Verfahrenstechnik (insg.)
- Katalyse
- Werkstoffwissenschaften (insg.)
- Elektronische, optische und magnetische Materialien
- Werkstoffwissenschaften (insg.)
- Keramische und Verbundwerkstoffe
- Chemie (insg.)
- Allgemeine Chemie
- Werkstoffwissenschaften (insg.)
- Oberflächen, Beschichtungen und Folien
- Werkstoffwissenschaften (insg.)
- Metalle und Legierungen
- Werkstoffwissenschaften (insg.)
- Werkstoffchemie
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in: Chemical communications, Jahrgang 2, Nr. 18, 01.01.2002, S. 2004-2005.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - A new synthesis of phosphoramidates
T2 - inhibitors of the key bacterial enzyme aspartate semi-aldehyde dehydrogenase
AU - Adams, Luke A.
AU - Cox, Russell J.
AU - Gibson, Jennifer S.
AU - Mayo-Martín, M. Belén
AU - Walter, Magnus
AU - Whittingham, William
PY - 2002/1/1
Y1 - 2002/1/1
N2 - A new, mild and high yielding synthesis of phosphoramidates is described: potassium salts of carboxylic acids are treated with ethylchloroformate and the resulting activated anhydride-carbonates are then treated with LiNHP(O)(OEt)2 in situ—the methodology is especially suited to acid sensitive systems featuring BOC,tBu or acetal protecting groups.
AB - A new, mild and high yielding synthesis of phosphoramidates is described: potassium salts of carboxylic acids are treated with ethylchloroformate and the resulting activated anhydride-carbonates are then treated with LiNHP(O)(OEt)2 in situ—the methodology is especially suited to acid sensitive systems featuring BOC,tBu or acetal protecting groups.
UR - http://www.scopus.com/inward/record.url?scp=0036400496&partnerID=8YFLogxK
U2 - 10.1039/b206199f
DO - 10.1039/b206199f
M3 - Article
C2 - 12357751
AN - SCOPUS:0036400496
VL - 2
SP - 2004
EP - 2005
JO - Chemical communications
JF - Chemical communications
SN - 1359-7345
IS - 18
ER -