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A mutation of the mitochondrial ABC transporter stat1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Autorschaft

  • S. Kushnir
  • E. Babiychuk
  • S. Storozhenko
  • M. W. Davey
  • J. Papenbrock

Externe Organisationen

  • Flanders Interuniversity Institute for Biotechnology
  • Universiteit Gent

Details

OriginalspracheEnglisch
Seiten (von - bis)89-100
Seitenumfang12
FachzeitschriftPLANT CELL
Jahrgang13
Ausgabenummer1
PublikationsstatusVeröffentlicht - 1 Jan. 2001
Extern publiziertJa

Abstract

A mutation in the Arabidopsis gene STARIK leads to dwarfism and chlorosis of plants with an altered morphology of leaf and cell nuclei. We show that the STARIK gene encodes the mitochondrial ABC transporter Sta1 that belongs to a subfamily of Arabidopsis half-ABC transporters. The severity of the starik phenotype is suppressed by the ectopic expression of the STA2 homolog; thus, Sta1 function is partially redundant. Sta1 supports the maturation of cytosolic Fe/S protein in Δatm1 yeast, substituting for the ABC transporter Atm1p. Similar to Atm1p-deficient yeast, mitochondria of the starik mutant accumulated more nonheme, nonprotein iron than did wild-type organelles. We further show that plant mitochondria contain a putative L-cysteine desulfurase. Taken together, our results suggest that plant mitochondria possess an evolutionarily conserved Fe/S cluster biosynthesis pathway, which is linked to the intracellular iron homeostasis by the function of Atm1p-like ABC transporters.

ASJC Scopus Sachgebiete

Zitieren

A mutation of the mitochondrial ABC transporter stat1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik. / Kushnir, S.; Babiychuk, E.; Storozhenko, S. et al.
in: PLANT CELL, Jahrgang 13, Nr. 1, 01.01.2001, S. 89-100.

Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review

Kushnir, S, Babiychuk, E, Storozhenko, S, Davey, MW, Papenbrock, J, De Rycke, R, Engler, G, Stephan, UW, Lange, H, Kispal, G, Lill, R & Van Montagu, M 2001, 'A mutation of the mitochondrial ABC transporter stat1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik', PLANT CELL, Jg. 13, Nr. 1, S. 89-100. https://doi.org/10.1105/tpc.13.1.89
Kushnir, S., Babiychuk, E., Storozhenko, S., Davey, M. W., Papenbrock, J., De Rycke, R., Engler, G., Stephan, U. W., Lange, H., Kispal, G., Lill, R., & Van Montagu, M. (2001). A mutation of the mitochondrial ABC transporter stat1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik. PLANT CELL, 13(1), 89-100. https://doi.org/10.1105/tpc.13.1.89
Kushnir S, Babiychuk E, Storozhenko S, Davey MW, Papenbrock J, De Rycke R et al. A mutation of the mitochondrial ABC transporter stat1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik. PLANT CELL. 2001 Jan 1;13(1):89-100. doi: 10.1105/tpc.13.1.89
Kushnir, S. ; Babiychuk, E. ; Storozhenko, S. et al. / A mutation of the mitochondrial ABC transporter stat1 leads to dwarfism and chlorosis in the Arabidopsis mutant starik. in: PLANT CELL. 2001 ; Jahrgang 13, Nr. 1. S. 89-100.
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abstract = "A mutation in the Arabidopsis gene STARIK leads to dwarfism and chlorosis of plants with an altered morphology of leaf and cell nuclei. We show that the STARIK gene encodes the mitochondrial ABC transporter Sta1 that belongs to a subfamily of Arabidopsis half-ABC transporters. The severity of the starik phenotype is suppressed by the ectopic expression of the STA2 homolog; thus, Sta1 function is partially redundant. Sta1 supports the maturation of cytosolic Fe/S protein in Δatm1 yeast, substituting for the ABC transporter Atm1p. Similar to Atm1p-deficient yeast, mitochondria of the starik mutant accumulated more nonheme, nonprotein iron than did wild-type organelles. We further show that plant mitochondria contain a putative L-cysteine desulfurase. Taken together, our results suggest that plant mitochondria possess an evolutionarily conserved Fe/S cluster biosynthesis pathway, which is linked to the intracellular iron homeostasis by the function of Atm1p-like ABC transporters.",
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AU - Babiychuk, E.

AU - Storozhenko, S.

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AU - De Rycke, R.

AU - Engler, G.

AU - Stephan, U. W.

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AU - Kispal, G.

AU - Lill, R.

AU - Van Montagu, M.

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