Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 57-65 |
| Seitenumfang | 9 |
| Fachzeitschrift | Statistics in Biopharmaceutical Research |
| Jahrgang | 4 |
| Ausgabenummer | 1 |
| Publikationsstatus | Veröffentlicht - 24 Mai 2012 |
Abstract
A modified Williams-type approach is proposed, which controls the family-wise error rate globally over both correlated endpoints and over dose comparisons. This order-restricted procedure is formulated for ratio-to-control comparisons, where the comparison of difference-to-control is included directly. Endpoint-specific variances are allowed, and even a modification for dose-group-specific variance heterogeneity is proposed. Therefore, this approach can be used simply for evaluation of real data by means of the R package SimComp. Both multiplicity-adjusted p-values and simultaneous confidence intervals are provided, whereas confidence intervals are clearly recommended to allow the interpretation for clinical relevance.
ASJC Scopus Sachgebiete
- Mathematik (insg.)
- Statistik und Wahrscheinlichkeit
- Pharmakologie, Toxikologie und Pharmazie (insg.)
- Pharmazeutische Wissenschaften
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in: Statistics in Biopharmaceutical Research, Jahrgang 4, Nr. 1, 24.05.2012, S. 57-65.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - A Multivariate Williams-Type Trend Procedure
AU - Hasler, Mario
AU - Hothorn, Ludwig A.
PY - 2012/5/24
Y1 - 2012/5/24
N2 - A modified Williams-type approach is proposed, which controls the family-wise error rate globally over both correlated endpoints and over dose comparisons. This order-restricted procedure is formulated for ratio-to-control comparisons, where the comparison of difference-to-control is included directly. Endpoint-specific variances are allowed, and even a modification for dose-group-specific variance heterogeneity is proposed. Therefore, this approach can be used simply for evaluation of real data by means of the R package SimComp. Both multiplicity-adjusted p-values and simultaneous confidence intervals are provided, whereas confidence intervals are clearly recommended to allow the interpretation for clinical relevance.
AB - A modified Williams-type approach is proposed, which controls the family-wise error rate globally over both correlated endpoints and over dose comparisons. This order-restricted procedure is formulated for ratio-to-control comparisons, where the comparison of difference-to-control is included directly. Endpoint-specific variances are allowed, and even a modification for dose-group-specific variance heterogeneity is proposed. Therefore, this approach can be used simply for evaluation of real data by means of the R package SimComp. Both multiplicity-adjusted p-values and simultaneous confidence intervals are provided, whereas confidence intervals are clearly recommended to allow the interpretation for clinical relevance.
KW - Correlated multiple endpoints
KW - Trend test
KW - Williams-type approach
UR - http://www.scopus.com/inward/record.url?scp=84865051053&partnerID=8YFLogxK
U2 - 10.1080/19466315.2011.633868
DO - 10.1080/19466315.2011.633868
M3 - Article
AN - SCOPUS:84865051053
VL - 4
SP - 57
EP - 65
JO - Statistics in Biopharmaceutical Research
JF - Statistics in Biopharmaceutical Research
SN - 1946-6315
IS - 1
ER -