Details
| Originalsprache | Englisch |
|---|---|
| Titel des Sammelwerks | TRANSDUCERS '03 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems |
| Untertitel | Digest of Technical Papers |
| Herausgeber (Verlag) | Institute of Electrical and Electronics Engineers Inc. |
| Seiten | 99-102 |
| Seitenumfang | 4 |
| ISBN (Print) | 0780377311 |
| Publikationsstatus | Veröffentlicht - 28 Juli 2003 |
| Extern publiziert | Ja |
| Veranstaltung | 12th International Conference on Solid-State Sensors, Actuators and Microsystems - Boston, USA / Vereinigte Staaten Dauer: 8 Juni 2003 → 12 Juni 2003 Konferenznummer: 12 |
Abstract
This paper presents a disposable minimally invasive self-calibrating continuous glucose monitor consisting of hollow out-of-plane microneedles to sample interstitial fluid from the epidermis, an integrated porous poly-Si dialysis membrane and an integrated enzyme-based flow-through glucose sensor. The proposed system can be fabricated on a wafer-level using standard MEMS technology and a novel in-device enzyme immobilization technique that allows wafer-level patterning of enzymes inside micro-scale flow channels after wafer bonding. This technique solves the compatibility issue of high temperature wafer bonding and temperature sensitive enzymes. A prototype of the glucose monitor is fabricated in order to demonstrate the high potential of out-of-plane microneedles for this application. Sampling of interstitial fluid through the microneedles results in a significant sensor response of the integrated glucose sensor.
ASJC Scopus Sachgebiete
- Ingenieurwesen (insg.)
- Elektrotechnik und Elektronik
Zitieren
- Standard
- Harvard
- Apa
- Vancouver
- BibTex
- RIS
TRANSDUCERS '03 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems: Digest of Technical Papers. Institute of Electrical and Electronics Engineers Inc., 2003. S. 99-102.
Publikation: Beitrag in Buch/Bericht/Sammelwerk/Konferenzband › Aufsatz in Konferenzband › Forschung › Peer-Review
}
TY - GEN
T1 - A microneedle-based glucose monitor
T2 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems
AU - Zimmermann, S.
AU - Fienbork, D.
AU - Stoeber, B.
AU - Flounders, A. W.
AU - Liepmann, D.
N1 - Conference code: 12
PY - 2003/7/28
Y1 - 2003/7/28
N2 - This paper presents a disposable minimally invasive self-calibrating continuous glucose monitor consisting of hollow out-of-plane microneedles to sample interstitial fluid from the epidermis, an integrated porous poly-Si dialysis membrane and an integrated enzyme-based flow-through glucose sensor. The proposed system can be fabricated on a wafer-level using standard MEMS technology and a novel in-device enzyme immobilization technique that allows wafer-level patterning of enzymes inside micro-scale flow channels after wafer bonding. This technique solves the compatibility issue of high temperature wafer bonding and temperature sensitive enzymes. A prototype of the glucose monitor is fabricated in order to demonstrate the high potential of out-of-plane microneedles for this application. Sampling of interstitial fluid through the microneedles results in a significant sensor response of the integrated glucose sensor.
AB - This paper presents a disposable minimally invasive self-calibrating continuous glucose monitor consisting of hollow out-of-plane microneedles to sample interstitial fluid from the epidermis, an integrated porous poly-Si dialysis membrane and an integrated enzyme-based flow-through glucose sensor. The proposed system can be fabricated on a wafer-level using standard MEMS technology and a novel in-device enzyme immobilization technique that allows wafer-level patterning of enzymes inside micro-scale flow channels after wafer bonding. This technique solves the compatibility issue of high temperature wafer bonding and temperature sensitive enzymes. A prototype of the glucose monitor is fabricated in order to demonstrate the high potential of out-of-plane microneedles for this application. Sampling of interstitial fluid through the microneedles results in a significant sensor response of the integrated glucose sensor.
KW - Biochemistry
KW - Biomembranes
KW - Epidermis
KW - Micromechanical devices
KW - Minimally invasive surgery
KW - Monitoring
KW - Prototypes
KW - Sugar
KW - Temperature sensors
KW - Wafer bonding
UR - http://www.scopus.com/inward/record.url?scp=4243108935&partnerID=8YFLogxK
U2 - 10.1109/SENSOR.2003.1215262
DO - 10.1109/SENSOR.2003.1215262
M3 - Conference contribution
AN - SCOPUS:4243108935
SN - 0780377311
SP - 99
EP - 102
BT - TRANSDUCERS '03 - 12th International Conference on Solid-State Sensors, Actuators and Microsystems
PB - Institute of Electrical and Electronics Engineers Inc.
Y2 - 8 June 2003 through 12 June 2003
ER -