A hyper-fast gas chromatograph coupled to an ion mobility spectrometer with high repetition rate and flow-optimized ion source to resolve the short chromatographic peaks

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autoren

  • Alexander Nitschke
  • Moritz Hitzemann
  • Jonas Winkelholz
  • Ansgar T. Kirk
  • Martin Lippmann
  • Christian Thoben
  • Jan A. Wittwer
  • Stefan Zimmermann
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Details

OriginalspracheEnglisch
Aufsatznummer465376
Seitenumfang9
FachzeitschriftJournal of Chromatography A
Jahrgang1736
Frühes Online-Datum12 Sept. 2024
PublikationsstatusVeröffentlicht - 8 Nov. 2024

Abstract

By combining the high selectivity of a gas chromatograph (GC) with the high sensitivity and decent selectivity of an ion mobility spectrometer (IMS), GC-IMS have become increasingly popular in many applications. However, most GC suffer from long analysis times. In contrast, an hyper-fast GC allows for extremely fast analysis in the tens of seconds while reaching comparably high resolution. In turn, coupling such hyper-fast GC with IMS requires sufficiently high repetition rate of recording full IMS spectra to resolve the short GC peaks. Therefore, we present a drift tube IMS with 100 Hz repetition rate. Key is a small effective detector volume combined with short drift length. Therefore, the ion source of the IMS combines a small reaction region with an extended field-switching ion shutter and optimized gas flows. To resolve even the shortest GC peaks with a full width at half maximum of 100 ms, a short drift length of just 41 mm was used, achieving a measurement time of 10 ms per spectrum and hence ten data points across the shortest GC peak. To avoid condensation of the sample, the entire IMS was heated isothermally to 120 °C. Despite short drift times and high temperatures, the IMS still reaches high resolving power of Rp = 60. The hyper-fast GC-IMS reaches low detection limits in the low ppbV range. For demonstration, ketone mixes and three different hop varieties were analyzed in <30 s.

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A hyper-fast gas chromatograph coupled to an ion mobility spectrometer with high repetition rate and flow-optimized ion source to resolve the short chromatographic peaks. / Nitschke, Alexander; Hitzemann, Moritz; Winkelholz, Jonas et al.
in: Journal of Chromatography A, Jahrgang 1736, 465376, 08.11.2024.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Nitschke A, Hitzemann M, Winkelholz J, Kirk AT, Lippmann M, Thoben C et al. A hyper-fast gas chromatograph coupled to an ion mobility spectrometer with high repetition rate and flow-optimized ion source to resolve the short chromatographic peaks. Journal of Chromatography A. 2024 Nov 8;1736:465376. Epub 2024 Sep 12. doi: 10.1016/j.chroma.2024.465376
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abstract = "By combining the high selectivity of a gas chromatograph (GC) with the high sensitivity and decent selectivity of an ion mobility spectrometer (IMS), GC-IMS have become increasingly popular in many applications. However, most GC suffer from long analysis times. In contrast, an hyper-fast GC allows for extremely fast analysis in the tens of seconds while reaching comparably high resolution. In turn, coupling such hyper-fast GC with IMS requires sufficiently high repetition rate of recording full IMS spectra to resolve the short GC peaks. Therefore, we present a drift tube IMS with 100 Hz repetition rate. Key is a small effective detector volume combined with short drift length. Therefore, the ion source of the IMS combines a small reaction region with an extended field-switching ion shutter and optimized gas flows. To resolve even the shortest GC peaks with a full width at half maximum of 100 ms, a short drift length of just 41 mm was used, achieving a measurement time of 10 ms per spectrum and hence ten data points across the shortest GC peak. To avoid condensation of the sample, the entire IMS was heated isothermally to 120 °C. Despite short drift times and high temperatures, the IMS still reaches high resolving power of Rp = 60. The hyper-fast GC-IMS reaches low detection limits in the low ppbV range. For demonstration, ketone mixes and three different hop varieties were analyzed in <30 s.",
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AU - Nitschke, Alexander

AU - Hitzemann, Moritz

AU - Winkelholz, Jonas

AU - Kirk, Ansgar T.

AU - Lippmann, Martin

AU - Thoben, Christian

AU - Wittwer, Jan A.

AU - Zimmermann, Stefan

N1 - Publisher Copyright: © 2024 The Author(s)

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