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A crucial role of L-selectin in C protein: Induced experimental polymyositis in mice

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Autorschaft

  • Kyosuke Oishi
  • Yasuhito Hamaguchi
  • Takashi Matsushita
  • Minoru Hasegawa
  • Naoko Okiyama
  • Jens Dernedde
  • Marie Weinhart
  • Rainer Haag
  • Thomas F. Tedder
  • Kazuhiko Takehara
  • Hitoshi Kohsaka
  • Manabu Fujimoto

Externe Organisationen

  • Kanazawa University
  • Tokyo Medical and Dental University
  • Charité - Universitätsmedizin Berlin
  • Freie Universität Berlin (FU Berlin)
  • Duke University
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Details

OriginalspracheEnglisch
Seiten (von - bis)1864-1871
Seitenumfang8
FachzeitschriftArthritis and Rheumatology
Jahrgang66
Ausgabenummer7
Frühes Online-Datum18 März 2014
PublikationsstatusVeröffentlicht - Juli 2014
Extern publiziertJa

Abstract

Objective To investigate the role of adhesion molecules in C protein-induced myositis (CIM), a murine model of polymyositis (PM). Methods CIM was induced in wild-type mice, L-selectin-deficient (L-selectin-/-) mice, intercellular adhesion molecule 1 (ICAM-1)-deficient (ICAM-1 -/-) mice, and mice deficient in both L-selectin and ICAM-1 (L-selectin-/-ICAM-1-/- mice). Myositis severity, inflammatory cell infiltration, and messenger RNA expression in the inflamed muscles were analyzed. The effect of dendritic polyglycerol sulfate, a synthetic inhibitor that suppresses the function of L-selectin and endothelial P-selectin, was also examined. Results L-selectin-/- mice and L-selectin-/-ICAM-1-/- mice developed significantly less severe myositis compared to wild-type mice, while ICAM-1 deficiency did not inhibit the development of myositis. L-selectin-/- mice that received wild-type T cells developed myositis. Treatment with dendritic polyglycerol sulfate significantly diminished the severity of myositis in wild-type mice compared to treatment with control. Conclusion These data indicate that L-selectin plays a major role in the development of CIM, whereas ICAM-1 plays a lesser role, if any, in the development of CIM. L-selectin-targeted therapy may be a candidate for the treatment of PM.

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Zitieren

A crucial role of L-selectin in C protein: Induced experimental polymyositis in mice. / Oishi, Kyosuke; Hamaguchi, Yasuhito; Matsushita, Takashi et al.
in: Arthritis and Rheumatology, Jahrgang 66, Nr. 7, 07.2014, S. 1864-1871.

Publikation: Beitrag in FachzeitschriftArtikelForschungPeer-Review

Oishi, K, Hamaguchi, Y, Matsushita, T, Hasegawa, M, Okiyama, N, Dernedde, J, Weinhart, M, Haag, R, Tedder, TF, Takehara, K, Kohsaka, H & Fujimoto, M 2014, 'A crucial role of L-selectin in C protein: Induced experimental polymyositis in mice', Arthritis and Rheumatology, Jg. 66, Nr. 7, S. 1864-1871. https://doi.org/10.1002/art.38630
Oishi, K., Hamaguchi, Y., Matsushita, T., Hasegawa, M., Okiyama, N., Dernedde, J., Weinhart, M., Haag, R., Tedder, T. F., Takehara, K., Kohsaka, H., & Fujimoto, M. (2014). A crucial role of L-selectin in C protein: Induced experimental polymyositis in mice. Arthritis and Rheumatology, 66(7), 1864-1871. https://doi.org/10.1002/art.38630
Oishi K, Hamaguchi Y, Matsushita T, Hasegawa M, Okiyama N, Dernedde J et al. A crucial role of L-selectin in C protein: Induced experimental polymyositis in mice. Arthritis and Rheumatology. 2014 Jul;66(7):1864-1871. Epub 2014 Mär 18. doi: 10.1002/art.38630
Oishi, Kyosuke ; Hamaguchi, Yasuhito ; Matsushita, Takashi et al. / A crucial role of L-selectin in C protein : Induced experimental polymyositis in mice. in: Arthritis and Rheumatology. 2014 ; Jahrgang 66, Nr. 7. S. 1864-1871.
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title = "A crucial role of L-selectin in C protein: Induced experimental polymyositis in mice",
abstract = "Objective To investigate the role of adhesion molecules in C protein-induced myositis (CIM), a murine model of polymyositis (PM). Methods CIM was induced in wild-type mice, L-selectin-deficient (L-selectin-/-) mice, intercellular adhesion molecule 1 (ICAM-1)-deficient (ICAM-1 -/-) mice, and mice deficient in both L-selectin and ICAM-1 (L-selectin-/-ICAM-1-/- mice). Myositis severity, inflammatory cell infiltration, and messenger RNA expression in the inflamed muscles were analyzed. The effect of dendritic polyglycerol sulfate, a synthetic inhibitor that suppresses the function of L-selectin and endothelial P-selectin, was also examined. Results L-selectin-/- mice and L-selectin-/-ICAM-1-/- mice developed significantly less severe myositis compared to wild-type mice, while ICAM-1 deficiency did not inhibit the development of myositis. L-selectin-/- mice that received wild-type T cells developed myositis. Treatment with dendritic polyglycerol sulfate significantly diminished the severity of myositis in wild-type mice compared to treatment with control. Conclusion These data indicate that L-selectin plays a major role in the development of CIM, whereas ICAM-1 plays a lesser role, if any, in the development of CIM. L-selectin-targeted therapy may be a candidate for the treatment of PM.",
author = "Kyosuke Oishi and Yasuhito Hamaguchi and Takashi Matsushita and Minoru Hasegawa and Naoko Okiyama and Jens Dernedde and Marie Weinhart and Rainer Haag and Tedder, {Thomas F.} and Kazuhiko Takehara and Hitoshi Kohsaka and Manabu Fujimoto",
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Download

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T1 - A crucial role of L-selectin in C protein

T2 - Induced experimental polymyositis in mice

AU - Oishi, Kyosuke

AU - Hamaguchi, Yasuhito

AU - Matsushita, Takashi

AU - Hasegawa, Minoru

AU - Okiyama, Naoko

AU - Dernedde, Jens

AU - Weinhart, Marie

AU - Haag, Rainer

AU - Tedder, Thomas F.

AU - Takehara, Kazuhiko

AU - Kohsaka, Hitoshi

AU - Fujimoto, Manabu

PY - 2014/7

Y1 - 2014/7

N2 - Objective To investigate the role of adhesion molecules in C protein-induced myositis (CIM), a murine model of polymyositis (PM). Methods CIM was induced in wild-type mice, L-selectin-deficient (L-selectin-/-) mice, intercellular adhesion molecule 1 (ICAM-1)-deficient (ICAM-1 -/-) mice, and mice deficient in both L-selectin and ICAM-1 (L-selectin-/-ICAM-1-/- mice). Myositis severity, inflammatory cell infiltration, and messenger RNA expression in the inflamed muscles were analyzed. The effect of dendritic polyglycerol sulfate, a synthetic inhibitor that suppresses the function of L-selectin and endothelial P-selectin, was also examined. Results L-selectin-/- mice and L-selectin-/-ICAM-1-/- mice developed significantly less severe myositis compared to wild-type mice, while ICAM-1 deficiency did not inhibit the development of myositis. L-selectin-/- mice that received wild-type T cells developed myositis. Treatment with dendritic polyglycerol sulfate significantly diminished the severity of myositis in wild-type mice compared to treatment with control. Conclusion These data indicate that L-selectin plays a major role in the development of CIM, whereas ICAM-1 plays a lesser role, if any, in the development of CIM. L-selectin-targeted therapy may be a candidate for the treatment of PM.

AB - Objective To investigate the role of adhesion molecules in C protein-induced myositis (CIM), a murine model of polymyositis (PM). Methods CIM was induced in wild-type mice, L-selectin-deficient (L-selectin-/-) mice, intercellular adhesion molecule 1 (ICAM-1)-deficient (ICAM-1 -/-) mice, and mice deficient in both L-selectin and ICAM-1 (L-selectin-/-ICAM-1-/- mice). Myositis severity, inflammatory cell infiltration, and messenger RNA expression in the inflamed muscles were analyzed. The effect of dendritic polyglycerol sulfate, a synthetic inhibitor that suppresses the function of L-selectin and endothelial P-selectin, was also examined. Results L-selectin-/- mice and L-selectin-/-ICAM-1-/- mice developed significantly less severe myositis compared to wild-type mice, while ICAM-1 deficiency did not inhibit the development of myositis. L-selectin-/- mice that received wild-type T cells developed myositis. Treatment with dendritic polyglycerol sulfate significantly diminished the severity of myositis in wild-type mice compared to treatment with control. Conclusion These data indicate that L-selectin plays a major role in the development of CIM, whereas ICAM-1 plays a lesser role, if any, in the development of CIM. L-selectin-targeted therapy may be a candidate for the treatment of PM.

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