Details
| Originalsprache | Englisch |
|---|---|
| Seiten (von - bis) | 2629-2636 |
| Seitenumfang | 8 |
| Fachzeitschrift | Journal of Materials Science: Materials in Medicine |
| Jahrgang | 19 |
| Ausgabenummer | 7 |
| Publikationsstatus | Veröffentlicht - 16 Jan. 2008 |
Abstract
The nanostructured surface of a material can improve its interaction with cells and its acceptance as an implant. We compared two novel biomaterials with different nanostructures: Bioverit® II with a coating of nanoporous silica and chitosan-hydroxyapatite composite materials. Pure Bioverit® II served as a control. Platelets of these materials were implanted for 28, 85 and 300 days in the subcutaneous tissue in the neck of 38 rabbits. After excising the specimens they were fixed, embedded in epoxy resin and analyzed histologically. All coated Bioverit® II implants showed a thin capsule of connective tissue. After 300 days, these capsules tended to be thicker than in pure Bioverit® II. No signs of inflammation were observed and the materials appeared unaltered by visual inspection. In case of chitosan-hydroxyapatite composites, massive capsules consisting of dense connective tissue were found, and the material showed signs of biodegradation in form of fissures and cavities. In conclusion, the nanoporous coating showed no obvious positive effect with regard to capsule formation; the chitosan-hydroxyapatite implants provoked a stronger interaction between cells and material. However, most Bioverit® II implants showed no alterations optically, whereas chitosan-hydroxyapatite was partly degraded in all cases.
ASJC Scopus Sachgebiete
- Biochemie, Genetik und Molekularbiologie (insg.)
- Biophysik
- Chemische Verfahrenstechnik (insg.)
- Bioengineering
- Werkstoffwissenschaften (insg.)
- Biomaterialien
- Ingenieurwesen (insg.)
- Biomedizintechnik
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in: Journal of Materials Science: Materials in Medicine, Jahrgang 19, Nr. 7, 16.01.2008, S. 2629-2636.
Publikation: Beitrag in Fachzeitschrift › Artikel › Forschung › Peer-Review
}
TY - JOUR
T1 - A comparison of different nanostructured biomaterials in subcutaneous tissue
AU - Vogt, Julia C.
AU - Brandes, Gudrun
AU - Krüger, Ilka
AU - Behrens, Peter
AU - Nolte, Ingo
AU - Lenarz, Thomas
AU - Stieve, Martin
N1 - Funding information: This work was supported by the German Research Foundation (DFG-SFB Collaborative Research Centre 599). The authors would like to thank Peter Erfurt from Department of Otolaryngology, Medical School Hannover, Hannover for technical support.
PY - 2008/1/16
Y1 - 2008/1/16
N2 - The nanostructured surface of a material can improve its interaction with cells and its acceptance as an implant. We compared two novel biomaterials with different nanostructures: Bioverit® II with a coating of nanoporous silica and chitosan-hydroxyapatite composite materials. Pure Bioverit® II served as a control. Platelets of these materials were implanted for 28, 85 and 300 days in the subcutaneous tissue in the neck of 38 rabbits. After excising the specimens they were fixed, embedded in epoxy resin and analyzed histologically. All coated Bioverit® II implants showed a thin capsule of connective tissue. After 300 days, these capsules tended to be thicker than in pure Bioverit® II. No signs of inflammation were observed and the materials appeared unaltered by visual inspection. In case of chitosan-hydroxyapatite composites, massive capsules consisting of dense connective tissue were found, and the material showed signs of biodegradation in form of fissures and cavities. In conclusion, the nanoporous coating showed no obvious positive effect with regard to capsule formation; the chitosan-hydroxyapatite implants provoked a stronger interaction between cells and material. However, most Bioverit® II implants showed no alterations optically, whereas chitosan-hydroxyapatite was partly degraded in all cases.
AB - The nanostructured surface of a material can improve its interaction with cells and its acceptance as an implant. We compared two novel biomaterials with different nanostructures: Bioverit® II with a coating of nanoporous silica and chitosan-hydroxyapatite composite materials. Pure Bioverit® II served as a control. Platelets of these materials were implanted for 28, 85 and 300 days in the subcutaneous tissue in the neck of 38 rabbits. After excising the specimens they were fixed, embedded in epoxy resin and analyzed histologically. All coated Bioverit® II implants showed a thin capsule of connective tissue. After 300 days, these capsules tended to be thicker than in pure Bioverit® II. No signs of inflammation were observed and the materials appeared unaltered by visual inspection. In case of chitosan-hydroxyapatite composites, massive capsules consisting of dense connective tissue were found, and the material showed signs of biodegradation in form of fissures and cavities. In conclusion, the nanoporous coating showed no obvious positive effect with regard to capsule formation; the chitosan-hydroxyapatite implants provoked a stronger interaction between cells and material. However, most Bioverit® II implants showed no alterations optically, whereas chitosan-hydroxyapatite was partly degraded in all cases.
UR - http://www.scopus.com/inward/record.url?scp=73149122794&partnerID=8YFLogxK
U2 - 10.1007/s10856-007-3353-6
DO - 10.1007/s10856-007-3353-6
M3 - Article
AN - SCOPUS:73149122794
VL - 19
SP - 2629
EP - 2636
JO - Journal of Materials Science: Materials in Medicine
JF - Journal of Materials Science: Materials in Medicine
SN - 0957-4530
IS - 7
ER -